IQSEC2 and PRMT2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		IQSEC2	PRMT2
Description		IQ motif and Sec7 domain ArfGEF 2	protein arginine methyltransferase 2
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GO Annotations	Cellular Component	Cytoplasm Schaffer Collateral - CA1 Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Transcription Coactivator Activity Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Nuclear Estrogen Receptor Binding Nuclear Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding Histone H3R8 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Long-term Synaptic Depression	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Developmental Cell Growth Negative Regulation Of Inflammatory Response Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Neutrophil count ( 32888494)	Diverticular disease ( 30177863)
Interacting Genes		6 interacting genes: CALM1 CALM2 CALM3 FOXP1 PRMT2 SNCA	37 interacting genes: BAG6 CBLB CHEK2 CPSF7 DAZAP1 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 IQSEC2 KDM6B MYO6 NCOA1 NCOA6 PGR PRMT8 PRRC2A PSMB3 R3HDM1 RB1 RBM12 RBM22 RIPK2 RXRA SHANK1 SHANK3 SHTN1 SPAG8 THRB WASL WBP11 YLPM1 ZFP36 ZNF341 ZSWIM8
Entrez ID		23096	3275
HPRD ID		10012	09060
Ensembl ID		ENSG00000124313	ENSG00000160310
Uniprot IDs		A0A1W2PR28 Q5JU85	A0A0S2Z3N3 P55345
PDB IDs		6FAE	1X2P
Enriched GO Terms of Interacting Partners?		Presynaptic Endocytosis Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Long-term Synaptic Potentiation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Titin Binding Detection Of Calcium Ion Vesicle-mediated Transport In Synapse Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Regulation Of Sequestering Of Calcium Ion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Synaptic Vesicle Membrane Negative Regulation Of Transporter Activity Calcium Channel Complex Presynaptic Cytosol Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Calcineurin-mediated Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Regulation Of Synaptic Plasticity Substantia Nigra Development Calcium Channel Regulator Activity Regulation Of Calcium Ion Transport Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Muscle System Process Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Monoatomic Cation Transmembrane Transport Neural Nucleus Development Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Complex	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Nucleus Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process MRNA Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Estrogen Response Element Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Dendritic Spine Morphogenesis Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Synaptic Receptor Adaptor Activity Regulation Of Transcription By RNA Polymerase II Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Dendritic Spine Organization RNA Binding Nuclear Estrogen Receptor Binding Neuron Projection Organization Postsynapse Organization Regulation Of Female Receptivity Female Mating Behavior MRNA Transcription By RNA Polymerase II
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