CAND2 and CNOT3

Number of citations of the paper that reports this interaction (PubMedID 12207886)
0

Data Source:
HPRD (two hybrid, in vitro)

		CAND2	CNOT3
Description		cullin associated and neddylation dissociated 2 (putative)	CCR4-NOT transcription complex subunit 3
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GO Annotations	Cellular Component	Nucleus Cytosol	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Protein Binding TBP-class Protein Binding	Protein Binding
	Biological Process	SCF Complex Assembly Protein Ubiquitination Positive Regulation Of DNA-templated Transcription	Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Cold-induced Thermogenesis Regulation Of Stem Cell Population Maintenance
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Creatine kinase levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HOMA-B (corrected for HOMA-IR) ( 30369944) P wave duration ( 28794112) Waist circumference adjusted for body mass index ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		9 interacting genes: CIDEB CNOT3 DNAJB6 FHL2 GLP1R RBX1 SYP TBP UBE3C	10 interacting genes: CAND1 CAND2 CNOT1 CNOT2 CNOT4 CNOT8 CREBBP ID3 OBI1 RUNX1
Entrez ID		23066	4849
HPRD ID		19120	05368
Ensembl ID		ENSG00000144712	ENSG00000088038
Uniprot IDs		O75155	O75175
PDB IDs		8VVY	4C0D 4C0G 5FU6 5FU7 9C3H 9C3I
Enriched GO Terms of Interacting Partners?			CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Poly(A)-specific Ribonuclease Activity Nuclear-transcribed MRNA Catabolic Process SCF Complex Assembly MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly P-body Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nucleobase-containing Compound Catabolic Process Trophectodermal Cell Differentiation Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process TBP-class Protein Binding Negative Regulation Of Biosynthetic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression MRNA Metabolic Process Protein Ubiquitination Transcription Coactivator Binding Negative Regulation Of Metabolic Process Cellular Response To Leptomycin B Leptomycin B Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Autoubiquitination Regulation Of Stem Cell Population Maintenance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
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