SBNO2 and TUBB4A

		SBNO2	TUBB4A
Description		strawberry notch homolog 2	tubulin beta 4A class IVa
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Axoneme Microtubule Cytoskeleton Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	Chromatin DNA Binding Histone Binding	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Ossification Macrophage Activation Involved In Immune Response Regulation Of DNA-templated Transcription Cell Differentiation Bone Mineralization Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Bone Trabecula Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-11 Cellular Response To Interleukin-6 Multinuclear Osteoclast Differentiation Osteoclast Fusion Cellular Response To Leukemia Inhibitory Factor	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Negative Regulation Of Microtubule Polymerization
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Epothilone D Patupilone CYT997 ZEN-012 Artenimol
Diseases
GWAS		Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Basal cell carcinoma ( 33549134) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Distal/Left-sided colorectal cancer ( 33632709) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010)	Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403)
Interacting Genes			15 interacting genes: BMPR2 CEBPA CLN8 FNDC3B LINC01554 NEAT1 NR4A1 OGT RBM11 RSPH1 SELENOF STAU1 STK11 SUMO2 YWHAG
Entrez ID		22904	10382
HPRD ID		17203	04045
Ensembl ID		ENSG00000064932	ENSG00000104833
Uniprot IDs		Q9Y2G9	M0QZL7 M0R1I1 M0R278 P04350
PDB IDs
Enriched GO Terms of Interacting Partners?		Internode Region Of Axon Negative Regulation Of Microtubule Polymerization Myelin Sheath Structural Constituent Of Cytoskeleton Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Supramolecular Fiber Organization Mitotic Spindle Mitotic Cell Cycle Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Or Depolymerization Axoneme Regulation Of Microtubule Polymerization Intercellular Bridge Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Microtubule Cytoskeleton GTPase Activity Microtubule Neuronal Cell Body GTP Binding Regulation Of Supramolecular Fiber Organization	Non-canonical Inflammasome Complex Assembly LncRNA-mediated Post-transcriptional Gene Silencing Cellular Developmental Process
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