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DENND3 and YAP1
Number of citations of the paper that reports this interaction (PMID
11278422
)
23
Data Source:
BioGRID
(two hybrid)
DENND3
YAP1
Gene Name
DENN/MADD domain containing 3
Yes-associated protein 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Membrane
Cell Junction
Molecular Function
Rab Guanyl-nucleotide Exchange Factor Activity
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Regulatory Region DNA Binding
Proline-rich Region Binding
Biological Process
Endosome To Lysosome Transport
Positive Regulation Of Rab GTPase Activity
Cellular Protein Catabolic Process
Cell Morphogenesis
Vasculogenesis
Embryonic Heart Tube Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To DNA Damage Stimulus
Cell Proliferation
Positive Regulation Of Cell Proliferation
Gene Expression
Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Notochord Development
Somatic Stem Cell Maintenance
Hippo Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Organ Growth
Paraxial Mesoderm Development
Lateral Mesoderm Development
Contact Inhibition
Cellular Response To Gamma Radiation
Regulation Of Stem Cell Proliferation
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Stem Cell Maintenance
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
PPARA activates gene expression
Nuclear signaling by ERBB4
Fatty acid, triacylglycerol, and ketone body metabolism
Signaling by Hippo
Generic Transcription Pathway
Metabolism of lipids and lipoproteins
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Signaling by ERBB4
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Response to interferon beta therapy (
21502966
)
MRI atrophy measures (
21116278
)
Polycystic ovary syndrome (
22885925
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Protein-Protein Interactions
1 interactors:
YAP1
28 interactors:
ABL1
AKT1
BTRC
DENND3
ERBB4
HNRNPU
KIF5A
LATS1
LATS2
NFE2
RUNX1
RUNX2
RUNX3
SCAMP3
SLC9A3R1
SMAD1
SMAD7
TEAD1
TEAD2
TEAD3
TEAD4
TP53BP2
TP63
TP73
WBP1
WBP2
YWHAG
YWHAQ
Entrez ID
22898
10413
HPRD ID
11114
09424
Ensembl ID
ENSG00000105339
ENSG00000137693
Uniprot IDs
A2RUS2
E9PF32
K0KVU2
P46937
Q86T74
PDB IDs
1JMQ
1K5R
1K9Q
1K9R
2LAW
2LAX
2LAY
2LTV
2LTW
3KYS
3MHR
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Stem Cell Maintenance
Contact Inhibition
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Lateral Mesoderm Development
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Cellular Response To Gamma Radiation
Regulation Of Epithelial Cell Differentiation Involved In Kidney Development
Regulation Of Keratinocyte Proliferation
Notochord Development
Regulation Of Stem Cell Maintenance
Paraxial Mesoderm Development
Hippo Signaling
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Organ Growth
Response To Gamma Radiation
Positive Regulation Of Stem Cell Differentiation
Cellular Response To Ionizing Radiation
Embryonic Heart Tube Morphogenesis
Somatic Stem Cell Maintenance
Embryonic Heart Tube Development
Keratinocyte Differentiation
Vasculogenesis
Regulation Of Organ Growth
Regulation Of Stem Cell Proliferation
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Epidermal Cell Differentiation
Cellular Response To Radiation
Regulation Of Epithelial Cell Differentiation
Response To Ionizing Radiation
Mesoderm Development
Stem Cell Maintenance
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of Developmental Growth
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Extrinsic Apoptotic Signaling Pathway
Mesenchyme Development
Positive Regulation Of Growth
Heart Morphogenesis
Regulation Of Canonical Wnt Signaling Pathway
DNA-templated Transcription, Initiation
Skin Development
Stem Cell Development
Negative Regulation Of Apoptotic Signaling Pathway
Epidermis Development
Regulation Of Epithelial Cell Proliferation
Regulation Of Developmental Growth
Regulation Of Wnt Signaling Pathway
Stem Cell Differentiation
Hippo Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Organ Development
Positive Regulation Of Gene Expression
Intracellular Signal Transduction
Positive Regulation Of Cellular Biosynthetic Process
System Development
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Multicellular Organismal Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Developmental Process
Anatomical Structure Development
Epithelium Development
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Metabolic Process
Response To Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Signaling
Regulation Of Metabolic Process
Positive Regulation Of Stem Cell Maintenance
Negative Regulation Of Phosphorylation
Signaling
Tissue Development
Cell Communication
Positive Regulation Of Cell Differentiation
Embryo Development
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Transferase Activity
Negative Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Regulation Of Cell Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Anatomical Structure Morphogenesis
Apoptotic Signaling Pathway
Regulation Of RNA Metabolic Process
Cell Differentiation
Negative Regulation Of Protein Kinase Activity
Negative Regulation Of Cellular Metabolic Process
Gene Expression
Response To Organic Substance
DNA-templated Transcription, Initiation
Tagcloud
?
alarco
albicans
balan
brefeldin
bzip
caglr1
cai4
cap1
catrr1
caycf1
cdr1
cdr2
cerulenin
cjd21
diamide
facilitator
fcz
flr1
fr2
hyperactive
hyperresistant
mainville
mdr1
nitroquinoline
phenanthroline
raymond
reintroduction
talibi
transformants
Tagcloud (Difference)
?
alarco
albicans
balan
brefeldin
bzip
caglr1
cai4
cap1
catrr1
caycf1
cdr1
cdr2
cerulenin
cjd21
diamide
facilitator
fcz
flr1
fr2
hyperactive
hyperresistant
mainville
mdr1
nitroquinoline
phenanthroline
raymond
reintroduction
talibi
transformants
Tagcloud (Intersection)
?