DENND3 and YAP1

Number of citations of the paper that reports this interaction (PMID 11278422)
23

Data Source:
BioGRID (two hybrid)

		DENND3	YAP1
Gene Name		DENN/MADD domain containing 3	Yes-associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Membrane Cell Junction
	Molecular Function	Rab Guanyl-nucleotide Exchange Factor Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Regulatory Region DNA Binding Proline-rich Region Binding
	Biological Process	Endosome To Lysosome Transport Positive Regulation Of Rab GTPase Activity Cellular Protein Catabolic Process	Cell Morphogenesis Vasculogenesis Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Cell Proliferation Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Somatic Stem Cell Maintenance Hippo Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Contact Inhibition Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			PPARA activates gene expression Nuclear signaling by ERBB4 Fatty acid, triacylglycerol, and ketone body metabolism Signaling by Hippo Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by ERBB4
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Response to interferon beta therapy ( 21502966)	MRI atrophy measures ( 21116278) Polycystic ovary syndrome ( 22885925) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		1 interactors: YAP1	28 interactors: ABL1 AKT1 BTRC DENND3 ERBB4 HNRNPU KIF5A LATS1 LATS2 NFE2 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP63 TP73 WBP1 WBP2 YWHAG YWHAQ
Entrez ID		22898	10413
HPRD ID		11114	09424
Ensembl ID		ENSG00000105339	ENSG00000137693
Uniprot IDs		A2RUS2 E9PF32	K0KVU2 P46937 Q86T74
PDB IDs			1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Maintenance Contact Inhibition Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Lateral Mesoderm Development Regulation Of Nephron Tubule Epithelial Cell Differentiation Cellular Response To Gamma Radiation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Regulation Of Keratinocyte Proliferation Notochord Development Regulation Of Stem Cell Maintenance Paraxial Mesoderm Development Hippo Signaling Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Organ Growth Response To Gamma Radiation Positive Regulation Of Stem Cell Differentiation Cellular Response To Ionizing Radiation Embryonic Heart Tube Morphogenesis Somatic Stem Cell Maintenance Embryonic Heart Tube Development Keratinocyte Differentiation Vasculogenesis Regulation Of Organ Growth Regulation Of Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Epidermal Cell Differentiation Cellular Response To Radiation Regulation Of Epithelial Cell Differentiation Response To Ionizing Radiation Mesoderm Development Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Developmental Growth Transcription Initiation From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Positive Regulation Of Growth Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway DNA-templated Transcription, Initiation Skin Development Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Epidermis Development Regulation Of Epithelial Cell Proliferation Regulation Of Developmental Growth Regulation Of Wnt Signaling Pathway Stem Cell Differentiation	Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Organ Development Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Cellular Biosynthetic Process System Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Developmental Process Anatomical Structure Development Epithelium Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Regulation Of Metabolic Process Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Phosphorylation Signaling Tissue Development Cell Communication Positive Regulation Of Cell Differentiation Embryo Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Cell Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Gene Expression Response To Organic Substance DNA-templated Transcription, Initiation
Tagcloud ?			alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
Tagcloud (Difference) ?			alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
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