DENND3

Gene Name		DENN/MADD domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component
	Molecular Function	Rab Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Endosome To Lysosome Transport Positive Regulation Of Rab GTPase Activity Cellular Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Response to interferon beta therapy ( 21502966)
Protein-protein Interactions		1 interactors: YAP1
Entrez ID		22898
HPRD ID		11114
Ensembl ID		ENSG00000105339
Uniprot IDs		A2RUS2 E9PF32
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stem Cell Maintenance Contact Inhibition Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Lateral Mesoderm Development Regulation Of Nephron Tubule Epithelial Cell Differentiation Cellular Response To Gamma Radiation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Regulation Of Keratinocyte Proliferation Notochord Development Regulation Of Stem Cell Maintenance Paraxial Mesoderm Development Hippo Signaling Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Organ Growth Response To Gamma Radiation Positive Regulation Of Stem Cell Differentiation Cellular Response To Ionizing Radiation Embryonic Heart Tube Morphogenesis Somatic Stem Cell Maintenance Embryonic Heart Tube Development Keratinocyte Differentiation Vasculogenesis Regulation Of Organ Growth Regulation Of Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Epidermal Cell Differentiation Cellular Response To Radiation Regulation Of Epithelial Cell Differentiation Response To Ionizing Radiation Mesoderm Development Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Developmental Growth Transcription Initiation From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Positive Regulation Of Growth Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway DNA-templated Transcription, Initiation Skin Development Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Epidermis Development Regulation Of Epithelial Cell Proliferation Regulation Of Developmental Growth Regulation Of Wnt Signaling Pathway Stem Cell Differentiation
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