FECH and ABCB7

Number of citations of the paper that reports this interaction (PMID 12480705)
12

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		FECH	ABCB7
Gene Name		ferrochelatase	ATP-binding cassette, sub-family B (MDR/TAP), member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Ferrochelatase Activity Protein Binding Ferrous Iron Binding Heme Binding Iron-responsive Element Binding 2 Iron, 2 Sulfur Cluster Binding	ATP Binding Heme Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Generation Of Precursor Metabolites And Energy Porphyrin-containing Compound Metabolic Process Heme Biosynthetic Process Cholesterol Metabolic Process Response To Light Stimulus Detection Of UV Response To Lead Ion Regulation Of Gene Expression Regulation Of EIF2 Alpha Phosphorylation By Heme Response To Insecticide Erythrocyte Differentiation Very-low-density Lipoprotein Particle Assembly Response To Drug Small Molecule Metabolic Process Response To Ethanol Protoporphyrinogen IX Metabolic Process Response To Arsenic-containing Substance Regulation Of Hemoglobin Biosynthetic Process Response To Methylmercury Iron Ion Homeostasis Response To Platinum Ion Cellular Response To Dexamethasone Stimulus	Transport Cellular Iron Ion Homeostasis Heme Transport Small Molecule Metabolic Process Transmembrane Transport
Pathways		Heme biosynthesis Metabolism of porphyrins	Mitochondrial ABC transporters ABC-family proteins mediated transport Cytosolic iron-sulfur cluster assembly
Drugs		Cholic Acid
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ABCB7	2 interactors: APP FECH
Entrez ID		2235	22
HPRD ID		01509	02137
Ensembl ID			ENSG00000131269
Uniprot IDs		B4DSA4 P22830 Q7KZA3	B4DGL8 G3XAC4 O75027 Q7Z3K5
PDB IDs		1HRK 2HRC 2HRE 2PNJ 2PO5 2PO7 2QD1 2QD2 2QD3 2QD4 2QD5 3AQI 3HCN 3HCO 3HCP 3HCR 4F4D 4MK4
Enriched GO Terms of Interacting Partners?		Heme Transport Cofactor Transport Cellular Iron Ion Homeostasis Iron Ion Homeostasis Transition Metal Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis	Cholesterol Metabolic Process Sterol Metabolic Process Transition Metal Ion Homeostasis Detection Of UV Steroid Metabolic Process Regulation Of EIF2 Alpha Phosphorylation By Heme Response To Platinum Ion Synaptic Growth At Neuromuscular Junction Response To Light Stimulus Alcohol Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Hemoglobin Biosynthetic Process Response To Radiation Collateral Sprouting Axon Midline Choice Point Recognition Metal Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Ion Homeostasis Very-low-density Lipoprotein Particle Assembly Neuron Remodeling Response To Methylmercury Protoporphyrinogen IX Metabolic Process Chemical Homeostasis Protein-lipid Complex Assembly Response To Insecticide Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Heme Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Response To Arsenic-containing Substance Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Lead Ion Cellular Response To Dexamethasone Stimulus Porphyrin-containing Compound Biosynthetic Process Mating Behavior Response To Dexamethasone Endoplasmic Reticulum Calcium Ion Homeostasis Lipid Metabolic Process RNA Polyadenylation Neuron Recognition Regulation Of Phosphorylation Heme Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homeostatic Process
Tagcloud ?		abcb6 ambp antioxidant beyond candidates chosen erythroid erythropoiesis followup fth1 ftl globin heme heterodimerizes hrg isothiocyanate k562 keap1 lymphoid maf nfe2 nfe2l2 nqo1 nrf2 seq sfn slc48a1 sulforaphane tbxas1	advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		abcb6 ambp antioxidant beyond candidates chosen erythropoiesis followup fth1 ftl globin heme heterodimerizes hrg isothiocyanate k562 keap1 lymphoid maf nfe2 nfe2l2 nqo1 nrf2 seq sfn slc48a1 sulforaphane tbxas1	advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?		erythroid