FECH and ABCB7

Number of citations: 0 (PubMedID 12480705)
Data Source: BioGRID (pull down, affinity chromatography technology), HPRD (in vitro, in vivo)

		FECH	ABCB7
Name		ferrochelatase	ATP binding cassette subfamily B member 7
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Ferrochelatase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Lyase Activity Heme Binding Iron-responsive Element Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Tetrapyrrole Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Nucleotide Binding Protein Binding ATP Binding Heme Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity ABC-type Transporter Activity ABC-type Iron-sulfur Cluster Transporter Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Cholesterol Metabolic Process Response To Xenobiotic Stimulus Response To Light Stimulus Detection Of UV Response To Metal Ion Response To Lead Ion Response To Insecticide Erythrocyte Differentiation Very-low-density Lipoprotein Particle Assembly Response To Ethanol Protoporphyrinogen IX Metabolic Process Response To Arsenic-containing Substance Regulation Of Hemoglobin Biosynthetic Process Heme O Biosynthetic Process Response To Methylmercury Multicellular Organismal-level Iron Ion Homeostasis Response To Platinum Ion Cellular Response To Dexamethasone Stimulus	Intracellular Iron Ion Homeostasis Heme Transport Iron-sulfur Cluster Assembly Iron Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Heme Biosynthetic Process Iron-sulfur Cluster Export From The Mitochondrion Positive Regulation Of Iron-sulfur Cluster Assembly Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		Heme biosynthesis Mitochondrial protein degradation	Mitochondrial ABC transporters Cytosolic iron-sulfur cluster assembly
Drugs		Cholic Acid	None
Diseases		Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP)	Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT)
GWAS		Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Migraine ( 27182965 ) Red cell distribution width ( 32888494 )	Metabolite levels ( 23823483 )
Interacting Genes		2 interacting genes: ABCB7 ATM	3 interacting genes: APP FECH UBC
Entrez ID		2235	22
HPRD ID		01509	02137
Ensembl ID		ENSG00000066926	ENSG00000131269
Uniprot IDs		A0A499FJN5 P22830	A0A087WW65 A0A0S2Z2Z3 O75027
PDB IDs		1HRK 2HRC 2HRE 2PNJ 2PO5 2PO7 2QD1 2QD2 2QD3 2QD4 2QD5 3AQI 3HCN 3HCO 3HCP 3HCR 3W1W 4F4D 4KLA 4KLC 4KLR 4KMM 4MK4 7CT7 7CTC	7VGF
GO Terms Enriched among Interactors		Iron-sulfur Cluster Export From The Mitochondrion Regulation Of Heme Biosynthetic Process ABC-type Iron-sulfur Cluster Transporter Activity Positive Regulation Of Heme Biosynthetic Process Positive Regulation Of Iron-sulfur Cluster Assembly Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA-dependent Protein Kinase Activity Positive Regulation Of Telomerase Catalytic Core Complex Assembly Histone H2AXS139 Kinase Activity Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Peptidyl-serine Autophosphorylation Heme Transmembrane Transporter Activity Heme Transport Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of Telomere Capping Response To Nitrosative Stress Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Telomere Localization Cellular Response To X-ray 1-phosphatidylinositol-3-kinase Activity Lipoprotein Catabolic Process Negative Regulation Of Collateral Sprouting Regulation Of Cellular Component Organization Iron Ion Transmembrane Transport Negative Regulation Of Reactive Oxygen Species Biosynthetic Process DNA Repair Complex Oocyte Development Extrinsic Component Of Synaptic Vesicle Membrane Regulation Of Telomere Capping Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Pexophagy Regulation Of Cellular Response To Heat Negative Regulation Of B Cell Proliferation Histone MRNA Catabolic Process Female Meiotic Nuclear Division V(D)J Recombination Iron-sulfur Cluster Assembly ATPase-coupled Transmembrane Transporter Activity Positive Regulation Of Vacuole Organization Lipoprotein Metabolic Process Female Gonad Development DNA Double-strand Break Processing	Response To Lead Ion Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Monoatomic Cation Homeostasis Mitochondrion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Detection Of UV Ferrochelatase Activity CAAX-box Protein Maturation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Chemical Homeostasis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tetrapyrrole Binding Iron-responsive Element Binding Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Response To Platinum Ion Myosin Filament Assembly Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Methylmercury Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Axon Choice Point Recognition Homeostatic Process