FECH

Name	ferrochelatase
Structure
Novel Interactors	1 novel interactors: DCC
Interactors	2 interactors: ABCB7 ATM
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	Ferrochelatase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Lyase Activity Heme Binding Iron-responsive Element Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Tetrapyrrole Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Cholesterol Metabolic Process Response To Xenobiotic Stimulus Response To Light Stimulus Detection Of UV Response To Metal Ion Response To Lead Ion Response To Insecticide Erythrocyte Differentiation Very-low-density Lipoprotein Particle Assembly Response To Ethanol Protoporphyrinogen IX Metabolic Process Response To Arsenic-containing Substance Regulation Of Hemoglobin Biosynthetic Process Heme O Biosynthetic Process Response To Methylmercury Multicellular Organismal-level Iron Ion Homeostasis Response To Platinum Ion Cellular Response To Dexamethasone Stimulus
Pathways	Heme biosynthesis Mitochondrial protein degradation
Drugs	Cholic Acid
Diseases	Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP)
GWAS	Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Migraine ( 27182965 ) Red cell distribution width ( 32888494 )
Entrez ID	2235
HPRD ID	01509
Ensembl ID	ENSG00000066926
Uniprot IDs	A0A499FJN5 P22830
PDB IDs	1HRK 2HRC 2HRE 2PNJ 2PO5 2PO7 2QD1 2QD2 2QD3 2QD4 2QD5 3AQI 3HCN 3HCO 3HCP 3HCR 3W1W 4F4D 4KLA 4KLC 4KLR 4KMM 4MK4 7CT7 7CTC
GO Terms Enriched among Interactors ?	Iron-sulfur Cluster Export From The Mitochondrion Regulation Of Heme Biosynthetic Process ABC-type Iron-sulfur Cluster Transporter Activity Positive Regulation Of Heme Biosynthetic Process Positive Regulation Of Iron-sulfur Cluster Assembly Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA-dependent Protein Kinase Activity Positive Regulation Of Telomerase Catalytic Core Complex Assembly Histone H2AXS139 Kinase Activity Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Peptidyl-serine Autophosphorylation Heme Transmembrane Transporter Activity Heme Transport Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Negative Regulation Of Telomere Capping Response To Nitrosative Stress Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development Telomere Localization Cellular Response To X-ray 1-phosphatidylinositol-3-kinase Activity Lipoprotein Catabolic Process Negative Regulation Of Collateral Sprouting Regulation Of Cellular Component Organization Iron Ion Transmembrane Transport Negative Regulation Of Reactive Oxygen Species Biosynthetic Process DNA Repair Complex Oocyte Development Extrinsic Component Of Synaptic Vesicle Membrane Regulation Of Telomere Capping Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Pexophagy Regulation Of Cellular Response To Heat Negative Regulation Of B Cell Proliferation Histone MRNA Catabolic Process Female Meiotic Nuclear Division V(D)J Recombination Iron-sulfur Cluster Assembly ATPase-coupled Transmembrane Transporter Activity Positive Regulation Of Vacuole Organization Lipoprotein Metabolic Process Female Gonad Development DNA Double-strand Break Processing