OARD1 and RAPGEF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OARD1	RAPGEF3
Description		O-acyl-ADP-ribose deacylase 1	Rap guanine nucleotide exchange factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Site Of DNA Damage	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Purine Nucleoside Binding Protein Binding Hydrolase Activity ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding
	Biological Process	DNA Damage Response Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation	Angiogenesis Adaptive Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Associative Learning Rap Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alzheimer's disease (late onset) ( 30820047) Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)	A body shape index ( 34021172) Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		4 interacting genes: APP PICK1 RAPGEF3 TNKS	14 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 TGFB1 UFSP1 ZRANB1
Entrez ID		221443	10411
HPRD ID		12849	06928
Ensembl ID		ENSG00000124596	ENSG00000079337
Uniprot IDs		C9J5P1 C9JA90 C9JXC3 Q05CR9 Q9Y530	O95398 Q99777
PDB IDs		2EEE 2L8R 2LGR 4J5Q 4J5R 4J5S	6H7E
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To CAMP Regulation Of Protein Transport Regulation Of Receptor Internalization Positive Regulation Of Receptor Internalization Glial Cell Development Response To CAMP Associative Learning Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Purine-containing Compound Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Receptor-mediated Endocytosis Learning Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cellular Component Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Plasma Membrane Bounded Cell Projection Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Synaptic Plasticity Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Norepinephrine Stimulus	Clathrin Adaptor Complex GDP Binding Rap Protein Signal Transduction Clathrin Adaptor Activity Response To Hydroperoxide GTP Binding Hydrolase Activity Intracellular Protein Localization Establishment Of Protein Localization Regulation Of Protein Localization To Membrane Regulation Of Response To Tumor Cell DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Liver Regeneration Regulation Of Collagen Metabolic Process Response To Ketone Regulation Of Collagen Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Viral RNA Genome Packaging Retrograde Axonal Protein Transport Primary Dendrite Response To Antineoplastic Agent Small GTPase-mediated Signal Transduction Animal Organ Regeneration G Protein Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Wortmannin Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Purine Nucleoside Binding DeUFMylase Activity
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