SKA3 and SPC24

Number of citations of the paper that reports this interaction (PMID 22371557)
17

Data Source:
BioGRID (two hybrid, two hybrid)

		SKA3	SPC24
Gene Name		spindle and kinetochore associated complex subunit 3	SPC24, NDC80 kinetochore complex component
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Gene Ontology Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytoplasm Spindle Microtubule	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Chromosome Segregation Mitotic Nuclear Division Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Mitotic Cell Cycle Mitotic Nuclear Division Cell Division
Pathways			Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			HDL cholesterol ( 23505323)
Protein-Protein Interactions		4 interactors: APP AURKB SPC24 ZDHHC17	5 interactors: APP PSEN2 SKA1 SKA2 SKA3
Entrez ID		221150	147841
HPRD ID		10706	15464
Ensembl ID		ENSG00000165480
Uniprot IDs		Q8IX90	B4DZZ7 Q8NBT2
PDB IDs		4AJ5	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Histone H3-S28 Phosphorylation Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Cycle Process Spindle Stabilization Regulation Of Binding Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Cell Cycle Abscission Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Nuclear Division Axon Choice Point Recognition Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Response To Light Stimulus Mitotic Spindle Elongation Neuron Remodeling Negative Regulation Of Cytokinesis Protein Localization To Kinetochore Spindle Midzone Assembly Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Cell Division Response To Radiation Regulation Of Cell Cycle Process Histone-serine Phosphorylation Cellular Copper Ion Homeostasis Regulation Of B Cell Apoptotic Process Mitotic Spindle Assembly Lipoprotein Transport Magnesium Ion Transport Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Protein Localization To Chromosome Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Palmitoylation Mitotic Cell Cycle Mating Behavior Positive Regulation Of Cytokinesis Regulation Of Signal Transduction Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Microtubule Depolymerization Microtubule-based Process	Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Chromosome Segregation Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Nuclear Division Cell Division Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Receptor Activity Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Regulation Of Organelle Organization Collateral Sprouting In Absence Of Injury Regulation Of Peptidyl-tyrosine Phosphorylation Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Cognition Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Cycle Neuron Remodeling Amyloid Precursor Protein Catabolic Process Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Forebrain Development Cellular Ion Homeostasis Single-organism Behavior Membrane Protein Intracellular Domain Proteolysis Metal Ion Homeostasis Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cellular Ketone Metabolic Process
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