SIGIRR and RPN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SIGIRR	RPN1
Gene Name		single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	ribophorin I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome
	Molecular Function	Protein Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Chemokine Biosynthetic Process	Translation Cellular Protein Modification Process SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade Innate Immune System	Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Translation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification SRP-dependent cotranslational protein targeting to membrane Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Monocyte count ( 23314186) White blood cell count ( 21738480)
Protein-Protein Interactions		9 interactors: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	13 interactors: ADRM1 ASB11 DPF1 ERBB3 HSPA5 RAD23A RBBP4 SGTA SIGIRR UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		59307	6184
HPRD ID		12018	01598
Ensembl ID		ENSG00000185187	ENSG00000163902
Uniprot IDs		C9JFX4 Q6IA17	P04843
PDB IDs
Enriched GO Terms of Interacting Partners?		MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Interleukin-1-mediated Signaling Pathway Regulation Of Innate Immune Response Immune Response Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Positive Regulation Of Interleukin-8 Production Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Immune Response-regulating Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Bacterium Positive Regulation Of Interleukin-12 Production Cellular Response To Interleukin-1 Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune System Process Regulation Of Interleukin-12 Production MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Defense Response Regulation Of MAP Kinase Activity Response To Other Organism Response To Interleukin-1 Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Kinase Activity Response To Biotic Stimulus Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Kinase Activity	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization
Tagcloud ?		1r acting affects autoimmune c3 c4 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages quantified scr sle sledai summary tlr z	26s adopts atp atph coexisting commitment conformational conformations cryo dataset deconvolutes deubiquitylation em ensemble essentially executes gammas hydrolyzing interpretable landscape lid machine module move polyubiquitylated proteasome rendered static topology
Tagcloud (Difference) ?		1r acting affects autoimmune c3 c4 cd4 circulating correlation cytometer erythematosus esr explored glucocorticoid hour immunoglobulin lupus mononuclear nephritis pbmcs percentages quantified scr sle sledai summary tlr z	26s adopts atp atph coexisting commitment conformational conformations cryo dataset deconvolutes deubiquitylation em ensemble essentially executes gammas hydrolyzing interpretable landscape lid machine module move polyubiquitylated proteasome rendered static topology
Tagcloud (Intersection) ?