SIGIRR and RPN1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		SIGIRR	RPN1
Description		single Ig and TIR domain containing	ribophorin I
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Melanosome Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Protein Binding	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Lymphocyte count ( 32888494)	Blood protein levels ( 30072576) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil count ( 27863252 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 32888494 29403010 27863252) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Serum metabolite levels ( 33031748) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 21738480 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	18 interacting genes: ADRM1 DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 PSMC2 RAD23A RBBP4 RBFOX2 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		59307	6184
HPRD ID		12018	01598
Ensembl ID		ENSG00000185187	ENSG00000163902
Uniprot IDs		C9JFX4 H0YDF8 H0YDR5 Q6IA17	P04843
PDB IDs			6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of Innate Immune Response Regulation Of Cytokine Production Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Activation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Response To Interleukin-1 Positive Regulation Of Immune System Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response Response To Lipopolysaccharide Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type II Interferon Production Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Interleukin-1-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Regulation Of Cytokine Production Involved In Immune Response Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Immune Response-activating Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Defense Response Regulation Of JNK Cascade Response To Lipid Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response	Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome Complex Regulation Of Cellular Response To Stress Positive Regulation Of ERAD Pathway Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of G0 To G1 Transition Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Metabolic Process Autophagosome Regulation Of Metabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Protein-containing Complex NBAF Complex Autophagosome Assembly Proteasome Binding Cytosol Autophagosome Organization Nucleoplasm Autophagy Regulation Of Primary Metabolic Process Regulation Of Nucleotide-excision Repair Regulation Of Double-strand Break Repair Nucleosomal DNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuole Organization Negative Regulation Of Transport
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