FLCN and FNIP1

Number of citations of the paper that reports this interaction (PMID 17028174)
73

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down, affinity chromatography technology)

		FLCN	FNIP1
Gene Name		folliculin	folliculin interacting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Midbody Cell-cell Contact Zone	Cytoplasm
	Molecular Function	Protein Binding Protein Complex Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell-cell Junction Assembly Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrion Organization Hemopoiesis Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Regulation Of Histone Acetylation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Energy Homeostasis Regulation Of Pro-B Cell Differentiation Negative Regulation Of ATP Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Immature B Cell Differentiation Positive Regulation Of B Cell Apoptotic Process Cellular Response To Starvation TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Pro-B Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP FNIP1	2 interactors: FLCN PRKAA1
Entrez ID		201163	96459
HPRD ID		06278	17233
Ensembl ID		ENSG00000154803	ENSG00000217128
Uniprot IDs		Q8NFG4	J3KNG8 Q8TF40
PDB IDs		3V42
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Negative Regulation Of Proteolysis Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Pro-B Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of B Cell Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Regulation Of Proteolysis Cell Activation Negative Regulation Of Catalytic Activity Immature B Cell Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Copper Ion Homeostasis Regulation Of B Cell Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process Apoptotic Process TOR Signaling Copper Ion Homeostasis Suckling Behavior Programmed Cell Death Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of TOR Signaling Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition	Regulation Of Energy Homeostasis Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Negative Regulation Of Glucosylceramide Biosynthetic Process Negative Regulation Of Energy Homeostasis Cold Acclimation Negative Regulation Of ATP Biosynthetic Process Negative Regulation Of Glucose Import In Response To Insulin Stimulus Response To Camptothecin Negative Regulation Of Intracellular Signal Transduction Regulation Of Pro-B Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Sphingolipid Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of MAPK Cascade Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Ethanol Negative Regulation Of Glucose Import Positive Regulation Of Protein Phosphorylation Positive Regulation Of Glycolytic Process Fatty Acid Homeostasis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Negative Regulation Of Glucose Transport Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Glucose Import In Response To Insulin Stimulus Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of TOR Signaling TOR Signaling Histone-serine Phosphorylation Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Glucose Starvation Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Response To Caffeine Regulation Of Glycolytic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cholesterol Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Mitochondrion Organization Positive Regulation Of Protein Metabolic Process Cholesterol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Autophagy
Tagcloud ?		bhlh circuitry commitment congruently destabilizing drives enforced epiblast esc escs esrrb exit fnip1 fnip2 folliculin ground integrates lies pluripotency pluripotent relocalization renewal restricting rheostat suppressors sustain tfe3 tsc2 withstand	bhlh circuitry commitment congruently destabilizing drives enforced epiblast esc escs esrrb exit flcn fnip2 folliculin ground integrates lies pluripotency pluripotent relocalization renewal restricting rheostat suppressors sustain tfe3 tsc2 withstand
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		bhlh circuitry commitment congruently destabilizing drives enforced epiblast esc escs esrrb exit flcn fnip1 fnip2 folliculin ground integrates lies pluripotency pluripotent relocalization renewal restricting rheostat suppressors sustain tfe3 tsc2 withstand