ELAVL4 and ELAVL2

Number of citations of the paper that reports this interaction (PubMedID 12384599)
44

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ELAVL4	ELAVL2
Description		ELAV like RNA binding protein 4	ELAV like RNA binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Axon Dendrite Growth Cone Cell Projection Perikaryon Ribonucleoprotein Complex	Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding MRNA 3'-UTR AU-rich Region Binding Pre-mRNA Intronic Pyrimidine-rich Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	RNA Processing MRNA Processing Learning Locomotory Behavior RNA Splicing Cerebral Cortex Neuron Differentiation Dendrite Morphogenesis 3'-UTR-mediated MRNA Stabilization Positive Regulation Of 3'-UTR-mediated MRNA Stabilization	Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413 26961502) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Male-pattern baldness ( 28196072) Obesity-related traits ( 23251661) Schizophrenia ( 30285260) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077)	Anxiety ( 33859377) Asthma ( 34103634 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Attending social / leisure activities ( 34054130) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Chronic obstructive pulmonary disease ( 30804561) Feeling guilty ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fulminant type 1 diabetes ( 30552108) General cognitive ability ( 29844566) Glomerular filtration rate change in heart transplantation ( 30160337) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intelligence (MTAG) ( 29326435) Lung function (FEV1/FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 27067015 29255261 27089181) Physiological traits ( 31902109) Plasma t-tau levels ( 28100725) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Schizophrenia ( 33169155) Sociability score ( 34054130)
Interacting Genes		6 interacting genes: ELAVL2 EWSR1 GAP43 NFX1 NXF1 PHF20L1	6 interacting genes: ELAVL3 ELAVL4 HNRNPAB HOXC9 NR2E3 RBFOX2
Entrez ID		1996	1993
HPRD ID		01343	03396
Ensembl ID		ENSG00000162374	ENSG00000107105
Uniprot IDs		A0A0R4J2E6 A0A494C0M6 A0A494C147 A0A494C1D9 B1APY9 P26378	A0A0A0MRX1 Q12926
PDB IDs		1FXL 1G2E
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding	Negative Regulation Of MRNA Catabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Ribonucleoprotein Complex MRNA 3'-UTR Binding Developmental Process MRNA 3'-UTR AU-rich Region Binding Nucleic Acid Binding Cellular Developmental Process MRNA Binding Negative Regulation Of RNA Metabolic Process RNA Metabolic Process MRNA Stabilization Cell Differentiation RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Stabilization Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Pre-mRNA Intronic Pyrimidine-rich Binding Negative Regulation Of Catabolic Process Nuclear Receptor-mediated Signaling Pathway Cellular Response To Cell-matrix Adhesion MRNA Editing Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Selenocysteine Insertion Sequence Binding Chromosomal 5-methylcytosine DNA Demethylation Pathway Hormone-mediated Signaling Pathway Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Nucleic Acid Metabolic Process Regulation Of Intracellular MRNA Localization Neuronal Ribonucleoprotein Granule Positive Regulation Of Gene Expression Interleukin-11-mediated Signaling Pathway MRNA Metabolic Process Neuron Development Selenocysteine Incorporation Regulation Of MRNA Stability Regulation Of RNA Metabolic Process Regulation Of RNA Stability Megakaryocyte Differentiation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Receptor Signaling Pathway
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