CELSR3 and PBRM1

		CELSR3	PBRM1
Description		cadherin EGF LAG seven-pass G-type receptor 3	polybromo 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Membrane	Nuclear Chromosome Kinetochore Chromatin Nucleus Nucleoplasm Chromosome Nuclear Matrix SWI/SNF Complex RSC-type Complex
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding	DNA Binding Chromatin Binding Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axonogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Cell-cell Adhesion Mediated By Cadherin Wnt Signaling Pathway, Planar Cell Polarity Pathway	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Formation of the polybromo-BAF (pBAF) complex
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mental health study participation (provided email address) ( 31263887) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Hemoglobin levels ( 32327693) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Intelligence (MTAG) ( 29326435) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Major mood disorders ( 20081856) Red cell distribution width ( 32888494) Schizophrenia ( 30285260 28991256 23974872 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		14 interacting genes: CLK1 CLUH DSCR9 DST IFT140 REST SCAPER SGSM2 SPTBN2 SPTBN4 SWAP70 TRIP12 TSPYL4 UACA	13 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 PTEN PTS SMARCA4 SUMO2 UBE3A USP7 ZDHHC17 ZNF512B
Entrez ID		1951	55193
HPRD ID		09179	07302
Ensembl ID		ENSG00000008300	ENSG00000163939
Uniprot IDs		Q9NYQ7	A0A9L9PXL4 Q86U86
PDB IDs			2KTB 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID 6OXB 6ZN6 6ZNV 6ZS3 6ZS4 7VDV 7Y8R 8FTA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Spectrin Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Protein-containing Complex Disassembly Actin Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Actin Filament Capping Cell Cortex Cell Junction Organization Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Amniotic Stem Cell Differentiation Negative Regulation Of Actin Filament Polymerization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Cytoskeleton Cortical Actin Cytoskeleton H Zone Negative Regulation Of Mesenchymal Stem Cell Differentiation Synapse Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Cerebellar Purkinje Cell Layer Morphogenesis Structural Constituent Of Postsynapse Heterochromatin Boundary Formation Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Chromatin Remodeling	Regulation Of Ubiquitin-dependent Protein Catabolic Process Structural Constituent Of Chromatin Regulation Of Proteolysis Chromatin Remodeling Nucleosome Epigenetic Regulation Of Gene Expression Nucleosome Organization Axonogenesis Protein Heterodimerization Activity Chromatin Organization Protein-DNA Complex Assembly Regulation Of MiRNA Transcription Positive Regulation Of Proteolysis Regulation Of MiRNA Metabolic Process System Development Neuron Projection Morphogenesis PML Body Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleosome Assembly Cell Projection Morphogenesis Negative Regulation Of MiRNA Transcription Postsynaptic Cytosol Positive Regulation Of Catabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Hormone Biosynthetic Process Negative Regulation Of Synaptic Vesicle Clustering 6-pyruvoyltetrahydropterin Synthase Activity Sperm Entry Positive Regulation Of Golgi Lumen Acidification Xylosylprotein 4-beta-galactosyltransferase Activity Perforant Pathway To Dendrate Granule Cell Synapse DNA Binding Neuron Projection Organization Regulation Of Protein Catabolic Process Negative Regulation Of Gene Expression, Epigenetic
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