PDE6C

Name	phosphodiesterase 6C
Structure
Novel Interactors	1 novel interactors: DVL3
Interactors	1 interactors: CDC42
GO Annotations	Cellular Component	Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	Nucleotide Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction Visual Perception Phototransduction, Visible Light Retinal Cone Cell Development Sensory Perception Of Light Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Drugs	Caffeine Trapidil
Diseases	Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS	Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid AB1-42 levels ( 29274321 ) Fasting glucose ( 34059833 ) Refractive error ( 32231278 )
Entrez ID	5146
HPRD ID	02898
Ensembl ID	ENSG00000095464
Uniprot IDs	P51160
PDB IDs	3JWQ 3JWR 5E8F 9CXG 9CXH 9CXI 9CXJ
GO Terms Enriched among Interactors ?	Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Wnt Signaling Pathway Apolipoprotein A-I Receptor Binding Regulation Of Actin Cytoskeleton Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament-based Process Small GTPase-mediated Signal Transduction Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Projection Organization Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cytoskeleton Organization Positive Regulation Of MAPK Cascade Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Golgi Localization Regulation Of Neuron Projection Arborization Cardiac Conduction System Development Establishment Of Epithelial Cell Apical/basal Polarity Cell Migration Involved In Heart Development Dendritic Spine Morphogenesis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Embryonic Heart Tube Development Intracellular Signaling Cassette Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Establishment Of Epithelial Cell Polarity