DSC2 and FHOD3

		DSC2	FHOD3
Description		desmocollin 2	formin homology 2 domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Endoplasmic Reticulum Plasma Membrane Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cytoplasmic Vesicle Extracellular Exosome Anchoring Junction	Cytoplasm Cytoskeleton Z Disc
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of P38MAPK Cascade	Actin Filament Organization Sarcomere Organization Positive Regulation Of Stress Fiber Assembly Cardiac Myofibril Assembly
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Blood protein levels ( 30072576) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738)	Adverse response to drug ( 30420678) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Height ( 31562340) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418 27841878) QRS duration ( 27659466) Response to antipsychotic treatment ( 20195266) Resting heart rate ( 29769521 27798624) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3
Entrez ID		1824	80206
HPRD ID		00512	16894
Ensembl ID		ENSG00000134755	ENSG00000134775
Uniprot IDs		A0A3B3ISU0 A0AAQ5BGT5 Q02487	Q2V2M9
PDB IDs		5ERP 5J5J 7A7D
Enriched GO Terms of Interacting Partners?		Desmosome Cornified Envelope Desmosome Organization Cell-cell Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Assembly Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Cell Junction Cell Junction Organization Homotypic Cell-cell Adhesion Cell Adhesion Regulation Of Cardiac Muscle Contraction Cell Junction Assembly Gamma-catenin Binding Cell Adhesion Molecule Binding Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Epithelial Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Regulation Of Muscle Contraction Maternal Process Involved In Female Pregnancy Response To Progesterone Protein Localization To Plasma Membrane Adherens Junction Regulation Of Heart Contraction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cytoplasm Cellular Component Assembly Regulation Of System Process Protein Localization To Cell Periphery Calcium Ion Binding Regulation Of Muscle System Process Regulation Of Blood Circulation Purkinje Myocyte Development	Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Intercalated Disc Positive Regulation Of P38MAPK Cascade Regulation Of Cardiac Muscle Cell Contraction Heterotypic Cell-cell Adhesion Desmosome Cardiac Conduction Regulation Of P38MAPK Cascade Regulation Of Action Potential Cornified Envelope Homotypic Cell-cell Adhesion Regulation Of Cardiac Muscle Contraction Regulation Of Heart Rate Regulation Of Striated Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Heart Contraction Cell Junction Regulation Of Muscle Contraction Cellular Response To Starvation Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Response To Starvation Regulation Of Blood Circulation Regulation Of Muscle System Process Cellular Response To Nutrient Levels Regulation Of Actin Filament-based Process
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