FHOD3

Description		formin homology 2 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Z Disc
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Sarcomere Organization Positive Regulation Of Stress Fiber Assembly Cardiac Myofibril Assembly
Pathways
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Height ( 31562340) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418 27841878) QRS duration ( 27659466) Response to antipsychotic treatment ( 20195266) Resting heart rate ( 29769521 27798624) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Novel Interacting Genes		1 novel interacting genes: DSC2
Interacting Genes
Entrez ID		80206
HPRD ID		16894
Ensembl ID		ENSG00000134775
Uniprot IDs		Q2V2M9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Intercalated Disc Positive Regulation Of P38MAPK Cascade Regulation Of Cardiac Muscle Cell Contraction Heterotypic Cell-cell Adhesion Desmosome Cardiac Conduction Regulation Of P38MAPK Cascade Regulation Of Action Potential Cornified Envelope Homotypic Cell-cell Adhesion Regulation Of Cardiac Muscle Contraction Regulation Of Heart Rate Regulation Of Striated Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Heart Contraction Cell Junction Regulation Of Muscle Contraction Cellular Response To Starvation Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Response To Starvation Regulation Of Blood Circulation Regulation Of Muscle System Process Cellular Response To Nutrient Levels Regulation Of Actin Filament-based Process
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