DSC2 and RO60

		DSC2	RO60
Description		desmocollin 2	Ro60, Y RNA binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Endoplasmic Reticulum Plasma Membrane Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cytoplasmic Vesicle Extracellular Exosome Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Nuclear Body Ribonucleoprotein Complex
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	RNA Binding U2 SnRNA Binding Metal Ion Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of P38MAPK Cascade	Immune System Development Transcription By RNA Polymerase III Smoothened Signaling Pathway Response To UV Regulation Of Gene Expression Cell Projection Organization Cellular Response To Interferon-alpha Cilium Assembly
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Blood protein levels ( 30072576) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483) Response to immune checkpoint inhibitors in melanoma (immune-related adverse events) ( 33409738)
Interacting Genes		6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3	8 interacting genes: CDC42 DDX6 FILNC1 OGT RAB11FIP5 RNY1 RNY3 TRIM21
Entrez ID		1824	6738
HPRD ID		00512	15964
Ensembl ID		ENSG00000134755	ENSG00000116747
Uniprot IDs		A0A3B3ISU0 A0AAQ5BGT5 Q02487	G5E9R9 P10155
PDB IDs		5ERP 5J5J 7A7D
Enriched GO Terms of Interacting Partners?		Desmosome Cornified Envelope Desmosome Organization Cell-cell Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Alpha-catenin Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Anchoring Junction Cell-cell Adhesion Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell-cell Junction Assembly Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Cell Junction Cell Junction Organization Homotypic Cell-cell Adhesion Cell Adhesion Regulation Of Cardiac Muscle Contraction Cell Junction Assembly Gamma-catenin Binding Cell Adhesion Molecule Binding Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Epithelial Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Regulation Of Muscle Contraction Maternal Process Involved In Female Pregnancy Response To Progesterone Protein Localization To Plasma Membrane Adherens Junction Regulation Of Heart Contraction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cytoplasm Cellular Component Assembly Regulation Of System Process Protein Localization To Cell Periphery Calcium Ion Binding Regulation Of Muscle System Process Regulation Of Blood Circulation Purkinje Myocyte Development
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