DYNC1H1 and PSMB9

		DYNC1H1	PSMB9
Description		dynein cytoplasmic 1 heavy chain 1	proteasome 20S subunit beta 9
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Cell Cortex Membrane Filopodium Dynein Complex Azurophil Granule Lumen Extracellular Exosome Axon Cytoplasm	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Minus-end-directed Microtubule Motor Activity Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Microtubule-based Movement Mitotic Spindle Organization Nuclear Migration Retrograde Axonal Transport Cytoplasmic Microtubule Organization Positive Regulation Of Intracellular Transport P-body Assembly Stress Granule Assembly Establishment Of Spindle Localization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Spindle Assembly	Immune System Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs			Carfilzomib
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 23266558) Disc degeneration (lumbar) ( 22993228) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Nephropathy ( 21399633) Platelet distribution width ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Systemic lupus erythematosus ( 32771030)
Interacting Genes		25 interacting genes: BRCA1 BTG3 CEBPA COX20 DISC1 DSCAM DSCR9 DUX4 DYNLL1 EGFR FILNC1 ITSN1 KATNA1 KATNB1 LINC01554 MTNR1B NDEL1 PRKCD RHBDD2 SMAD2 SUMO2 TENT5A TNIK YWHAG YWHAQ	8 interacting genes: CRYGA DDIT4L LAGE3 NCOA1 NCOA2 NCOA3 POMP PSMB10
Entrez ID		1778	5698
HPRD ID		02524	01514
Ensembl ID		ENSG00000197102	ENSG00000240065
Uniprot IDs		Q14204	A0A1U9X8D7 P28065
PDB IDs		5NUG 5OWO 6F1T 6F1U 6F1V 6F1Y 6F38 6F3A 7Z8F 7Z8G 7Z8H 7Z8I 7Z8J 7Z8K 7Z8L 8DYU 8DYV 8FCY 8FD6 8FDT 8FDU 8PQV 8PQW 8PQY 8PQZ 8PR0 8PR1 8PR2 8PR3 8PTK	6AVO 6E5B 7AWE 7B12 9FST
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing BRCA1-C Complex Cerebral Cortex Cell Migration Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Telencephalon Cell Migration Signal Transduction Forebrain Cell Migration Microtubule Severing	Cellular Response To Thyroglobulin Triiodothyronine Nuclear Receptor Binding Response To Thyroglobulin Triiodothyronine Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Nuclear Receptor-mediated Signaling Pathway Regulation Of Adipose Tissue Development Protein-lysine-acetyltransferase Activity Protein Dimerization Activity Histone Acetyltransferase Activity Response To Progesterone Intracellular Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose MRNA Transcription Transcription Coactivator Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Labyrinthine Layer Morphogenesis Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Neural Tube Closure Tube Closure Response To Lipid Positive Regulation Of Female Receptivity Response To Retinoic Acid Histone H3K14ac Reader Activity Response To Estradiol Vitamin D Receptor Signaling Pathway
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