DNAH8 and RASGRP1

		DNAH8	RASGRP1
Description		dynein axonemal heavy chain 8	RAS guanyl releasing protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Outer Dynein Arm Cell Projection 9+2 Motile Cilium	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Phosphatidylcholine Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Microtubule-based Movement Outer Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility	Positive Regulation Of Protein Phosphorylation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune System Process Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Secretory Granule Localization Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Intracellular Signal Transduction
Pathways			Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Circulating leptin levels in high cardiovascular risk ( 31766143) Femur bone mineral density x serum urate levels interaction ( 34046847) Smoking status (heavy vs never) ( 26423011)	Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 23128233 28067908) Estimated glomerular filtration rate ( 30604766) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 32723749 24390342 30423114 23143596 30572963) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 33272962 28714469) Type 1 diabetes ( 25751624 21829393 18840781) Type 2 diabetes ( 30718926 30297969 32499647 28254843 22961080)
Interacting Genes			2 interacting genes: DGKZ HRAS
Entrez ID		1769	10125
HPRD ID		04515	04909
Ensembl ID		ENSG00000124721	ENSG00000172575
Uniprot IDs		A0A075B6F3 Q8IU65 Q96JB1	B2RA89 O95267
PDB IDs			4L9M 4L9U
Enriched GO Terms of Interacting Partners?		Leukocyte Degranulation Mast Cell Degranulation Inflammatory Response To Antigenic Stimulus Lysosome Localization Regulated Exocytosis Histamine Secretion Mediated By IgE Immunoglobulin Exocytosis Establishment Of Organelle Localization Establishment Of Localization In Cell Histamine Secretion By Mast Cell Secretion By Cell Immune Effector Process Positive Regulation Of T Cell Differentiation In Thymus Histamine Transport Histamine Secretion Mitochondrial Outer Membrane Translocase Complex TOM Complex Positive Regulation Of Natural Killer Cell Differentiation Organelle Localization Diacylglycerol Binding Regulation Of Natural Killer Cell Differentiation Response To Histamine Specific Granule Protein Insertion Into Mitochondrial Outer Membrane Secretion Inflammatory Response Positive Regulation Of Ras Protein Signal Transduction Secretory Granule Localization Calcium Ion Binding Activation Of GTPase Activity Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Natural Killer Cell Activation GTPase Regulator Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylcholine Binding Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Positive Regulation Of MAP Kinase Activity Positive Regulation Of Natural Killer Cell Mediated Immunity B Cell Proliferation Regulation Of Natural Killer Cell Activation Vesicle Transport Along Microtubule Regulation Of Ras Protein Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Azurophil Granule Membrane Vesicle Cytoskeletal Trafficking Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity
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