DNAH8

Description		dynein axonemal heavy chain 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Outer Dynein Arm Cell Projection 9+2 Motile Cilium
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Microtubule-based Movement Outer Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility
Pathways
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Circulating leptin levels in high cardiovascular risk ( 31766143) Femur bone mineral density x serum urate levels interaction ( 34046847) Smoking status (heavy vs never) ( 26423011)
Novel Interacting Genes		3 novel interacting genes: RAB44 RASGRP1 TOMM6
Interacting Genes
Entrez ID		1769
HPRD ID		04515
Ensembl ID		ENSG00000124721
Uniprot IDs		A0A075B6F3 Q8IU65 Q96JB1
PDB IDs
Enriched GO Terms of Interacting Partners?		Leukocyte Degranulation Mast Cell Degranulation Inflammatory Response To Antigenic Stimulus Lysosome Localization Regulated Exocytosis Histamine Secretion Mediated By IgE Immunoglobulin Exocytosis Establishment Of Organelle Localization Establishment Of Localization In Cell Histamine Secretion By Mast Cell Secretion By Cell Immune Effector Process Positive Regulation Of T Cell Differentiation In Thymus Histamine Transport Histamine Secretion Mitochondrial Outer Membrane Translocase Complex TOM Complex Positive Regulation Of Natural Killer Cell Differentiation Organelle Localization Diacylglycerol Binding Regulation Of Natural Killer Cell Differentiation Response To Histamine Specific Granule Protein Insertion Into Mitochondrial Outer Membrane Secretion Inflammatory Response Positive Regulation Of Ras Protein Signal Transduction Secretory Granule Localization Calcium Ion Binding Activation Of GTPase Activity Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Natural Killer Cell Activation GTPase Regulator Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylcholine Binding Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Positive Regulation Of MAP Kinase Activity Positive Regulation Of Natural Killer Cell Mediated Immunity B Cell Proliferation Regulation Of Natural Killer Cell Activation Vesicle Transport Along Microtubule Regulation Of Ras Protein Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Azurophil Granule Membrane Vesicle Cytoskeletal Trafficking Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity
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