DNAH8 and TOMM6

		DNAH8	TOMM6
Description		dynein axonemal heavy chain 8	translocase of outer mitochondrial membrane 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Outer Dynein Arm Cell Projection 9+2 Motile Cilium	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane TOM Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding
	Biological Process	Microtubule-based Movement Outer Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility	Protein Transport Protein Insertion Into Mitochondrial Outer Membrane
Pathways			Mitochondrial protein import PINK1-PRKN Mediated Mitophagy
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Circulating leptin levels in high cardiovascular risk ( 31766143) Femur bone mineral density x serum urate levels interaction ( 34046847) Smoking status (heavy vs never) ( 26423011)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes			14 interacting genes: AQP6 C1orf159 CD68 CERS4 ERGIC3 FFAR3 GLP1R HUNK ODF4 SEC61A2 SLC10A1 SLC16A2 SLC18A2 TMEM14B
Entrez ID		1769	100188893
HPRD ID		04515	19464
Ensembl ID		ENSG00000124721	ENSG00000214736
Uniprot IDs		A0A075B6F3 Q8IU65 Q96JB1	Q96B49
PDB IDs			7CK6 7CP9 7VBY 7VC4 7VD2 7VDD 8XVA 9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Leukocyte Degranulation Mast Cell Degranulation Inflammatory Response To Antigenic Stimulus Lysosome Localization Regulated Exocytosis Histamine Secretion Mediated By IgE Immunoglobulin Exocytosis Establishment Of Organelle Localization Establishment Of Localization In Cell Histamine Secretion By Mast Cell Secretion By Cell Immune Effector Process Positive Regulation Of T Cell Differentiation In Thymus Histamine Transport Histamine Secretion Mitochondrial Outer Membrane Translocase Complex TOM Complex Positive Regulation Of Natural Killer Cell Differentiation Organelle Localization Diacylglycerol Binding Regulation Of Natural Killer Cell Differentiation Response To Histamine Specific Granule Protein Insertion Into Mitochondrial Outer Membrane Secretion Inflammatory Response Positive Regulation Of Ras Protein Signal Transduction Secretory Granule Localization Calcium Ion Binding Activation Of GTPase Activity Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Natural Killer Cell Activation GTPase Regulator Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylcholine Binding Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Positive Regulation Of MAP Kinase Activity Positive Regulation Of Natural Killer Cell Mediated Immunity B Cell Proliferation Regulation Of Natural Killer Cell Activation Vesicle Transport Along Microtubule Regulation Of Ras Protein Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Azurophil Granule Membrane Vesicle Cytoskeletal Trafficking Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity	Post-translational Protein Targeting To Membrane, Translocation Hormone Secretion Hormone Transport Transmembrane Transport Membrane Intracellular Protein Transmembrane Transport Signal Release Nitrate Transmembrane Transporter Activity Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Blood Pressure Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Regulation Of Hormone Levels PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Thyroid-stimulating Hormone Secretion Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Protein Transmembrane Transport Glucagon Receptor Activity Histamine Uptake Serotonin:sodium:chloride Symporter Activity
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