DIO3 and C1QBP

		DIO3	C1QBP
Description		iodothyronine deiodinase 3	complement C1q binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Endosome Membrane Membrane	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Thyroxine 5'-deiodinase Activity Oxidoreductase Activity Thyroxine 5-deiodinase Activity	Complement Component C1q Complex Binding Transcription Corepressor Activity MRNA Binding Enzyme Inhibitor Activity Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Kininogen Binding Adrenergic Receptor Binding Deoxyribonuclease Inhibitor Activity C5-methylcytidine-containing RNA Reader Activity Mitochondrial Ribosome Binding
	Biological Process	Response To Hypoxia Apoptotic Process Positive Regulation Of Multicellular Organism Growth Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Retinal Cone Cell Development Brown Fat Cell Proliferation Retinal Cone Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Mitochondrial RNA Catabolic Process Adaptive Immune Response Immune System Process MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway DNA Damage Response RNA Splicing Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Ribosome Biogenesis Cytosolic Ribosome Assembly Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Regulation of thyroid hormone activity	Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation RHOA GTPase cycle RHOC GTPase cycle Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Drugs		Iopodic acid	Hyaluronic acid Copper
Diseases
GWAS		Metabolite levels ( 23823483) Pulse pressure ( 30224653) Type 1 diabetes ( 19966805)	Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		3 interacting genes: APP PRMT5 PRMT7	105 interacting genes: C1QA CDK13 CEBPA COIL DUX4 EXOSC6 FOXP1 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK KLF1 MAPK1 MAPK3 MBD1 MBD2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SHANK3 SRSF1 SRSF9 TOP3B ULK1 YWHAB YWHAG
Entrez ID		1735	708
HPRD ID		11867	03168
Ensembl ID		ENSG00000197406	ENSG00000108561
Uniprot IDs		P55073 Q86TU3	Q07021
PDB IDs			1P32 3RPX 6SZW 7TE3
Enriched GO Terms of Interacting Partners?		Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine N-methyltransferase Activity Epigenetic Regulation Of Gene Expression Histone Methyltransferase Activity Protein Methylation Ribonucleoprotein Complex Binding Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Spliceosomal SnRNP Assembly Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Adrenergic Receptor Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Type II Interferon Production Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Kininogen Binding Deoxyribonuclease Inhibitor Activity Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Futile Creatine Cycle Peptidyl-arginine N-methylation Histone Arginine N-methyltransferase Activity Macromolecule Methylation Methyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chromatin Organization Cellular Response To Norepinephrine Stimulus	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vasculature Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Developmental Process Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Developmental Process Negative Regulation Of Blood Vessel Endothelial Cell Migration
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