ASXL1 and SRM

		ASXL1	SRM
Description		ASXL transcriptional regulator 1	spermidine synthase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PR-DUB Complex	Cytosol
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Catalytic Activity Spermidine Synthase Activity Protein Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Morphogenesis Heart Morphogenesis Chromatin Organization Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Hematopoietic Or Lymphoid Organ Development Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Bone Development Lung Saccule Development Podocyte Development	Polyamine Metabolic Process Polyamine Biosynthetic Process Spermidine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		UCH proteinases	Metabolism of polyamines
Drugs
Diseases		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Beard thickness ( 26926045)
Interacting Genes		8 interacting genes: APP BAP1 BRD4 FOXK1 GOLGA6L9 SRPK1 STAT3 UBC	4 interacting genes: CDC42 CEBPA SOX12 TERF1
Entrez ID		171023	6723
HPRD ID		16516	01692
Ensembl ID		ENSG00000171456	ENSG00000116649
Uniprot IDs		A0A2R8Y5U1 Q498B9 Q8IXJ9	P19623
PDB IDs		8H1T 8SVF	2O05 2O06 2O07 2O0L 3RW9
Enriched GO Terms of Interacting Partners?		Neutrophil Differentiation Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Inflammatory Response Chromatin Binding Granulocyte Differentiation Fatty Acid Synthase Activity [acyl-carrier-protein] S-acetyltransferase Activity [acyl-carrier-protein] S-malonyltransferase Activity (3R)-hydroxyacyl-[acyl-carrier-protein] Dehydratase Activity Fatty Acyl-[ACP] Hydrolase Activity Phosphopantetheine Binding Spermidine Synthase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Histone H4K8ac Reader Activity	Positive Regulation Of Cell Adhesion Macrophage Differentiation GBD Domain Binding Storage Vacuole RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 Positive Regulation Of Cell Activation C/EBP Complex Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Adaptive Immune Memory Response Endothelin Receptor Signaling Pathway Involved In Heart Process Myeloid Leukocyte Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Fat Cell Differentiation CHOP-C/EBP Complex Regulation Of Cell Activation Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway White Fat Cell Proliferation PR-DUB Complex Positive Regulation Of Metabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Adhesion Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Phenylpropanoid Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Lung Saccule Development Bone Marrow Development Regulation Of Kidney Size Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Establishment Of Golgi Localization Spindle DNA Binding Fat Cell Proliferation Meiotic Telomere Clustering
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?