KCNG3 and CEP250

		KCNG3	CEP250
Description		potassium voltage-gated channel modifier subfamily G member 3	centrosomal protein 250
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Spindle Pole Centrosome Protein-containing Complex Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport	Mitotic Cell Cycle Intracellular Protein Localization Centriole-centriole Cohesion Cell Projection Organization Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Protein Localization To Centrosome Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways		Voltage gated Potassium channels	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Enflurane Promethazine Miconazole
Diseases
GWAS		Body mass index ( 25673413) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thrombosis ( 26908601)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 18391951 25429064 34270706) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: KCNB1 KCNB2 KCNC1 KCNF1	7 interacting genes: APP ATF7IP KAT2B NEK2 PLEKHA5 USP7 YWHAG
Entrez ID		170850	11190
HPRD ID		16232	09877
Ensembl ID		ENSG00000171126	ENSG00000126001
Uniprot IDs		Q8TAE7	A0A9L9PXD2 Q9BV73
PDB IDs			6OQA
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Neuronal Cell Body Membrane Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Potassium Channel Regulator Activity Protein Complex Oligomerization Regulation Of Membrane Potential Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Inorganic Ion Transmembrane Transport Dendrite Membrane Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Ion Transport Non-motile Cilium Assembly Neuronal Cell Body Transmembrane Transport Cellular Component Assembly Dendrite Cell Projection Protein-containing Complex Assembly Regulation Of Potassium Ion Transport Localization Within Membrane Protein-containing Complex Organization Transmembrane Transporter Binding Perikaryon Regulation Of Transport Positive Regulation Of Norepinephrine Secretion Globus Pallidus Development Gated Channel Activity Neuron Projection Membrane Regulation Of Centriole-centriole Cohesion Clustering Of Voltage-gated Potassium Channels Intracellular Protein Localization Protein Localization To Plasma Membrane Positive Regulation Of Long-term Synaptic Depression Positive Regulation Of Protein Localization To Centrosome Protein Localization To Cell Periphery Postsynaptic Membrane Proximal Dendrite Cholesterol Catabolic Process Cilium Assembly	Regulation Of TOR Signaling Negative Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Protein Catabolic Process Positive Regulation Of Glycolytic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Protein-containing Complex Chromatin Organization Positive Regulation Of ATP Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol Negative Regulation Of Centriole-centriole Cohesion Regulation Of Gluconeogenesis Protein Stabilization Positive Regulation Of Catabolic Process Regulation Of Chromosome Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Positive Regulation Of Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cell Cycle Regulation Of Centriole-centriole Cohesion Negative Regulation Of TORC1 Signaling TOR Signaling Protein Kinase C Inhibitor Activity Cellular Response To Nutrient Levels TORC1 Signaling Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of RRNA Processing
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