DEFB4A and CCR6

Number of citations of the paper that reports this interaction (PMID 11714836)
43

Data Source:
HPRD (in vitro, in vivo)

		DEFB4A	CCR6
Gene Name		defensin, beta 4A	chemokine (C-C motif) receptor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Golgi Lumen	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function		Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity
	Biological Process	Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response	Dendritic Cell Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Innate Immune Response Chemokine-mediated Signaling Pathway
Pathways		Beta defensins Defensins Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Beta defensins Defensins G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 20570966 21102463) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453841 20453842) Vitiligo ( 20526339)
Protein-Protein Interactions		2 interactors: CCR6 TLR4	4 interactors: CCL20 DEFB1 DEFB103B DEFB4A
Entrez ID		1673	1235
HPRD ID		03739	03498
Ensembl ID		ENSG00000171711	ENSG00000112486
Uniprot IDs		O15263	P51684
PDB IDs		1E4Q 1FD3 1FD4 1FQQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Negative Regulation Of Interleukin-23 Production Nitric Oxide Production Involved In Inflammatory Response Detection Of Lipopolysaccharide Intestinal Epithelial Structure Maintenance Inflammatory Response Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway B Cell Proliferation Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Platelet Activation Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Interferon-beta Biosynthetic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Dendritic Cell Chemotaxis Detection Of Molecule Of Bacterial Origin Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Innate Immune Response I-kappaB Phosphorylation Maintenance Of Gastrointestinal Epithelium Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process Interferon-gamma Production Epithelial Structure Maintenance Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Macrophage Cytokine Production Dendritic Cell Migration Positive Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Production Of Molecular Mediator Involved In Inflammatory Response T-helper 1 Type Immune Response Detection Of Biotic Stimulus Macrophage Activation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-10 Production Regulation Of Platelet Activation Positive Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Blood Coagulation Negative Regulation Of Interferon-gamma Production Defense Response To Gram-negative Bacterium Immune Response Negative Regulation Of Interleukin-6 Production	Defense Response To Bacterium Response To Bacterium Response To Other Organism Response To Biotic Stimulus Immune Response Defense Response Response To External Stimulus Chemotaxis Immune System Process Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process Response To Stress Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria Locomotion Positive Regulation Of Antimicrobial Humoral Response Regulation Of Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Defense Response To Bacterium Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Lipoteichoic Acid Positive Regulation Of Humoral Immune Response Innate Immune Response In Mucosa Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Antibacterial Humoral Response Antimicrobial Humoral Response Regulation Of Lymphocyte Migration Mucosal Immune Response Positive Regulation Of Interleukin-1 Production Response To Testosterone Response To Lipid Positive Regulation Of Immune System Process Regulation Of Humoral Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Acute Inflammatory Response G-protein Coupled Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Leukocyte Migration Regulation Of Immune System Process Regulation Of Cytokine Biosynthetic Process Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Cell Chemotaxis
Tagcloud ?			confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly
Tagcloud (Difference) ?			confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly
Tagcloud (Intersection) ?