DEFB4A

Gene Name		defensin, beta 4A
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Gene Ontology Annotations	Cellular Component	Extracellular Region Golgi Lumen
	Molecular Function
	Biological Process	Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response
Pathways		Beta defensins Defensins Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: CCR6 TLR4
Entrez ID		1673
HPRD ID		03739
Ensembl ID		ENSG00000171711
Uniprot IDs		O15263
PDB IDs		1E4Q 1FD3 1FD4 1FQQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Negative Regulation Of Interleukin-23 Production Nitric Oxide Production Involved In Inflammatory Response Detection Of Lipopolysaccharide Intestinal Epithelial Structure Maintenance Inflammatory Response Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway B Cell Proliferation Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Platelet Activation Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Interferon-beta Biosynthetic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Dendritic Cell Chemotaxis Detection Of Molecule Of Bacterial Origin Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Innate Immune Response I-kappaB Phosphorylation Maintenance Of Gastrointestinal Epithelium Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process Interferon-gamma Production Epithelial Structure Maintenance Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Macrophage Cytokine Production Dendritic Cell Migration Positive Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Production Of Molecular Mediator Involved In Inflammatory Response T-helper 1 Type Immune Response Detection Of Biotic Stimulus Macrophage Activation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Interleukin-10 Production Regulation Of Platelet Activation Positive Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Blood Coagulation Negative Regulation Of Interferon-gamma Production Defense Response To Gram-negative Bacterium Immune Response Negative Regulation Of Interleukin-6 Production
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