DEFB4A

Description		defensin beta 4A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity
	Biological Process	Chemotaxis Defense Response Immune Response G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Positive Chemotaxis Cell Chemotaxis Antifungal Innate Immune Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont
Pathways		Beta defensins Defensins
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: CCR6 KCNA3 TLR4
Entrez ID		1673
HPRD ID		03739
Ensembl ID		ENSG00000171711
Uniprot IDs		O15263
PDB IDs		1E4Q 1FD3 1FD4 1FQQ 6CS9 8YD6
Enriched GO Terms of Interacting Partners?		B Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Cell Activation Involved In Immune Response B Cell Activation Lymphocyte Activation Involved In Immune Response Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Negative Regulation Of Interleukin-23 Production Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Detection Of Fungus Nitric Oxide Production Involved In Inflammatory Response Wound Healing Involved In Inflammatory Response MHC Class II Biosynthetic Process Thymocyte Migration Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Signaling Receptor Activity DN2 Thymocyte Differentiation Lipopolysaccharide Receptor Complex Mononuclear Cell Differentiation T Cell Activation Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Detection Of Lipopolysaccharide B Cell Proliferation Involved In Immune Response External Side Of Plasma Membrane Lipopolysaccharide Immune Receptor Activity Leukocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Immune Effector Process Sperm Plasma Membrane Positive Regulation Of Flagellated Sperm Motility Voltage-gated Monoatomic Ion Channel Activity Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-23 Production Cellular Response To Lipoteichoic Acid Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Intestinal Epithelial Structure Maintenance TRIF-dependent Toll-like Receptor Signaling Pathway NK T Cell Activation Microglia Differentiation T-helper 1 Type Immune Response Regulation Of Dendritic Cell Chemotaxis Lymphocyte Activation Positive Regulation Of Cilium Movement Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Detection Of Molecule Of Bacterial Origin Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Platelet Activation
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