DEFA3

Description		defensin alpha 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protein Homodimerization Activity Pore-forming Activity
	Biological Process	Innate Immune Response In Mucosa Defense Response Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Defensins Alpha-defensins
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Dental caries (decayed and filled deciduous teeth) ( 31533690) Monocyte percentage of white cells ( 32888494)
Interacting Genes		1 interacting genes: DEFA1
Entrez ID		1668
HPRD ID		05159
Ensembl ID		ENSG00000239839
Uniprot IDs		P59666 Q6EZE9
PDB IDs		1DFN 1ZMH 1ZMI 1ZMK 2PM4 2PM5
Enriched GO Terms of Interacting Partners?		Disruption Of Plasma Membrane Integrity In Another Organism Pore-forming Activity Biological Process Involved In Interaction With Symbiont Lymphocyte Chemotaxis Mucosal Immune Response Defense Response To Protozoan T Cell Migration Killing By Host Of Symbiont Cells Innate Immune Response In Mucosa T Cell Chemotaxis Estrogen Receptor Signaling Pathway Response To Protozoan Organ Or Tissue Specific Immune Response Lymphocyte Migration Defense Response To Fungus Response To Fungus Antibacterial Humoral Response Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Defense Response To Gram-negative Bacterium Azurophil Granule Lumen Golgi Lumen Nuclear Receptor-mediated Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Mononuclear Cell Migration Defense Response To Gram-positive Bacterium Leukocyte Chemotaxis Hormone-mediated Signaling Pathway Antimicrobial Humoral Response Cell Killing Cell Chemotaxis Intracellular Receptor Signaling Pathway Leukocyte Migration Humoral Immune Response Defense Response To Virus Defense Response To Bacterium Chemotaxis Locomotion Response To Virus Response To Bacterium
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