DCLK2 and TSC22D3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DCLK2	TSC22D3
Description		doublecortin like kinase 2	TSC22 domain family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Central Nervous System Development Hippocampus Development Pyramidal Neuron Development Protein Localization To Nucleus Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Activation-induced Cell Death Of T Cells
Pathways			Stimuli-sensing channels
Drugs		Fostamatinib
Diseases
GWAS		Alcohol use disorder (consumption score) ( 30940813) Coronary artery disease ( 26708285) HDL cholesterol levels ( 32109663) Leukocyte telomere length ( 32109421) Myocardial infarction ( 26708285) Psychological resilience (self-assessed) ( 31081985) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Rosacea symptom severity ( 29771307) Social autistic-like traits ( 24133439) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		3 interacting genes: BTG3 CCDC57 TSC22D3	15 interacting genes: BRME1 DCLK2 FOS HPCAL4 JUN MAD1L1 MTA2 NFKB1 NFKB2 PLEKHF2 RAF1 REL RELA SUMO1 UFL1
Entrez ID		166614	1831
HPRD ID		13122	04266
Ensembl ID		ENSG00000170390	ENSG00000157514
Uniprot IDs		Q8N568	Q99576
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Activation-induced Cell Death Of T Cells Negative Regulation Of Activation-induced Cell Death Of T Cells	Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Response To Mechanical Stimulus NF-kappaB P50/p65 Complex Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex I-kappaB/NF-kappaB Complex Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signaling Cassette NF-kappaB Complex Transcription Factor AP-1 Complex DNA-binding Transcription Factor Activity Positive Regulation Of MiRNA Transcription Chromatin Cellular Response To Nicotine Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of MiRNA Transcription Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process General Transcription Initiation Factor Binding Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Actinin Binding Response To Peptide Response To Cytokine Cellular Response To Tumor Necrosis Factor Gland Development Cellular Response To Angiotensin Cellular Response To Interleukin-6 Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Lipopolysaccharide Response To Interleukin-6 RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Tumor Necrosis Factor Response To Molecule Of Bacterial Origin
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