DDX10 and DSC3

		DDX10	DSC3
Description		DEAD-box helicase 10	desmocollin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Cornified Envelope Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Cell Junction Desmosome Anchoring Junction
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Calcium Ion Binding Gamma-catenin Binding Metal Ion Binding
	Biological Process	RRNA Processing Anterior Head Development	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization Cell-cell Adhesion
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases			Hypotrichosis and recurrent skin vesicles
GWAS		Bipolar disorder ( 34099189) Femur bone mineral density x serum urate levels interaction ( 34046847) Knee osteoarthritis ( 28916551) Systolic blood pressure ( 27841878)	Bronchopulmonary dysplasia ( 23897914) Hand grip strength (Mahalanobis distance) ( 32235003) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Supraventricular ectopy ( 29618737) Type 2 diabetes ( 31049640)
Interacting Genes		4 interacting genes: APP FBXO7 RNF10 SIRPA	5 interacting genes: CTNNB1 JUP PKP3 PKP4 UCHL5
Entrez ID		1662	1825
HPRD ID		03138	02604
Ensembl ID		ENSG00000178105	ENSG00000134762
Uniprot IDs		Q13206	Q14574
PDB IDs		2PL3
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of System Process Lipoprotein Particle Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Import Regulation Of Nitric Oxide Metabolic Process Insulin-like Growth Factor Binary Complex Maintenance Of Protein Location In Nucleus Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location Maintenance Of Protein Location In Cell 6-pyruvoyltetrahydropterin Synthase Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Symbiont-mediated Suppression Of Host Innate Immune Response SCF Ubiquitin Ligase Complex GTPase Regulator Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Carotene Metabolic Process Xanthophyll Catabolic Process Zeaxanthin Catabolic Process Carotenoid Dioxygenase Activity 9,10 (9', 10')-carotenoid-cleaving Dioxygenase Activity Lutein Catabolic Process Beta,beta-carotene-9',10'-cleaving Oxygenase Activity Carotene Catabolic Process Xanthophyll Metabolic Process Lycopene Catabolic Process Cellular Response To Interleukin-12 PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Maintenance Of Location In Cell Maintenance Of Location	Desmosome Adherens Junction Cornified Envelope Alpha-catenin Binding Cell-cell Junction Assembly Anchoring Junction Cell-cell Junction Organization Cell-cell Adhesion Catenin-TCF7L2 Complex Intercalated Disc Cell-cell Junction Cell Junction Cellular Response To Indole-3-methanol Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cell Junction Assembly Response To Indole-3-methanol Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Cadherin Binding Cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Cell Junction Organization Epithelial Cell-cell Adhesion Catenin Complex Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Midbrain Development Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Regulation Of Cell Adhesion Cardiac Conduction Skin Development Regulation Of Action Potential Homotypic Cell-cell Adhesion Positive Regulation Of Telomere Maintenance Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Gamma-catenin-TCF7L2 Complex Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction Regulation Of Embryonic Development Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex
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