DDX3X and GABRE

		DDX3X	GABRE
Description		DEAD-box helicase 3 X-linked	gamma-aminobutyric acid type A receptor subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Membrane Cytosolic Small Ribosomal Subunit Lamellipodium Cell Leading Edge Secretory Granule Lumen Cell Projection P Granule Canonical Inflammasome Complex Extracellular Exosome NLRP3 Inflammasome Complex Ficolin-1-rich Granule Lumen	Plasma Membrane Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Postsynapse GABA-A Receptor Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding GTPase Activity Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Signaling Adaptor Activity RNA Stem-loop Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding CTPase Activity Protein Serine/threonine Kinase Activator Activity Cadherin Binding MRNA 5'-UTR Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity GABA-gated Chloride Ion Channel Activity
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Translational Initiation Regulation Of Translation Apoptotic Process Chromosome Segregation Gamete Generation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Stress Granule Assembly Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Ribosome Biogenesis Cytosolic Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Lipid Homeostasis Positive Regulation Of Mitochondrial Translation Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein K63-linked Ubiquitination Protein Localization To Cytoplasmic Stress Granule Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Chloride Transmembrane Transport Inhibitory Synapse Assembly Negative Regulation Of Chloride Transport
Pathways		Neutrophil degranulation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Refractive error ( 32231278)
Interacting Genes		101 interacting genes: ANXA1 APBB1 CEBPA CRYAA CSNK2A1 DSCR9 DUX4 ESR1 HNF4A IKBKE IL7R LINC01232 LINC01554 MAVS MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NFKB2 NUP62 OGT PIN1 SREK1 SRPK2 SUMO2 TRIM25 USP7 USP9X WBP4 XPO1 YWHAQ ZNF512B
Entrez ID		1654	2564
HPRD ID		02154	02104
Ensembl ID		ENSG00000215301	ENSG00000102287
Uniprot IDs		A0A2R8YDT5 A0A2R8YFS5 O00571	P78334
PDB IDs		2I4I 2JGN 3JRV 4O2C 4O2E 4O2F 4PX9 4PXA 5E7I 5E7J 5E7M 6CZ5 6O5F 7LIU 8SSW
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Communication Regulation Of MRNA Metabolic Process	Positive Regulation Of Protein K63-linked Ubiquitination RNA Strand Annealing Activity NLRP3 Inflammasome Complex Cytosolic Ribosome Assembly Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Translation In Response To Stress CTPase Activity Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Eukaryotic Initiation Factor 4E Binding Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Mitochondrial Translation Regulation Of Translation In Response To Endoplasmic Reticulum Stress Canonical Inflammasome Complex RNA Stem-loop Binding Regulation Of Protein K63-linked Ubiquitination Eukaryotic Translation Initiation Factor 3 Complex Ribosomal Small Subunit Binding Ribonucleoside Triphosphate Phosphatase Activity Positive Regulation Of Mitochondrial Translation P Granule Transcription Factor Binding Positive Regulation Of Protein Polyubiquitination Ribosome Assembly Poly(A) Binding Cellular Response To Arsenic-containing Substance Regulation Of Translation In Response To Stress Translation Initiation Factor Binding MRNA 5'-UTR Binding Stress Granule Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Interferon-alpha Production Response To Arsenic-containing Substance Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Viral Genome Replication Regulation Of Protein Polyubiquitination Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Gamma-tubulin Binding Cytosolic Small Ribosomal Subunit DNA Helicase Activity Positive Regulation Of Interferon-beta Production Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition
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