GABRE

Description		gamma-aminobutyric acid type A receptor subunit epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Postsynapse GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity GABA-gated Chloride Ion Channel Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Chloride Transmembrane Transport Inhibitory Synapse Assembly Negative Regulation Of Chloride Transport
Pathways
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: DDX3X
Interacting Genes
Entrez ID		2564
HPRD ID		02104
Ensembl ID		ENSG00000102287
Uniprot IDs		P78334
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein K63-linked Ubiquitination RNA Strand Annealing Activity NLRP3 Inflammasome Complex Cytosolic Ribosome Assembly Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Translation In Response To Stress CTPase Activity Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Eukaryotic Initiation Factor 4E Binding Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Mitochondrial Translation Regulation Of Translation In Response To Endoplasmic Reticulum Stress Canonical Inflammasome Complex RNA Stem-loop Binding Regulation Of Protein K63-linked Ubiquitination Eukaryotic Translation Initiation Factor 3 Complex Ribosomal Small Subunit Binding Ribonucleoside Triphosphate Phosphatase Activity Positive Regulation Of Mitochondrial Translation P Granule Transcription Factor Binding Positive Regulation Of Protein Polyubiquitination Ribosome Assembly Poly(A) Binding Cellular Response To Arsenic-containing Substance Regulation Of Translation In Response To Stress Translation Initiation Factor Binding MRNA 5'-UTR Binding Stress Granule Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Interferon-alpha Production Response To Arsenic-containing Substance Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Viral Genome Replication Regulation Of Protein Polyubiquitination Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Gamma-tubulin Binding Cytosolic Small Ribosomal Subunit DNA Helicase Activity Positive Regulation Of Interferon-beta Production Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition
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