DDC and ATF6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DDC	ATF6
Gene Name		dopa decarboxylase (aromatic L-amino acid decarboxylase)	activating transcription factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Synaptic Vesicle Axon Neuronal Cell Body Extracellular Vesicular Exosome	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Aromatic-L-amino-acid Decarboxylase Activity Protein Binding Amino Acid Binding Enzyme Binding Protein Domain Specific Binding Pyridoxal Phosphate Binding L-dopa Decarboxylase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding CAMP Response Element Binding
	Biological Process	Cellular Amino Acid Metabolic Process Circadian Rhythm Multicellular Organismal Aging Synaptic Vesicle Amine Transport Isoquinoline Alkaloid Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Drug Dopamine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Small Molecule Metabolic Process Indolalkylamine Biosynthetic Process Response To Pyrethroid Phytoalexin Metabolic Process Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Folding Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Amine-derived hormones Serotonin and melatonin biosynthesis Catecholamine biosynthesis Metabolism of amino acids and derivatives	ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperone genes ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs		Pyridoxal Phosphate Carbidopa
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23512250 19684603) Malaria ( 19465909)	Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		3 interactors: AR ATF6 RELA	14 interactors: APP ATF6B BPGM CREB1 CREB3L3 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		1644	22926
HPRD ID		00145	16118
Ensembl ID		ENSG00000132437	ENSG00000118217
Uniprot IDs		P20711 Q53Y41	A8K383 P18850
PDB IDs		3RBF 3RBL 3RCH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Integrin Biosynthetic Process Acetaldehyde Metabolic Process Positive Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Schwann Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Integrin Biosynthetic Process Regulation Of Schwann Cell Differentiation Response To Cobalamin Regulation Of Integrin Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of MiRNA Metabolic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Transcription, DNA-templated Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process RNA Biosynthetic Process Response To Steroid Hormone Positive Regulation Of Transcription From RNA Polymerase III Promoter Response To Organic Substance Gland Development Positive Regulation Of Cellular Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Response To Muramyl Dipeptide Response To UV-B Membrane Protein Intracellular Domain Proteolysis RNA Metabolic Process Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Metabolic Process Gene Expression Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Interleukin-6 Positive Regulation Of Chondrocyte Differentiation	Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Response To Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To Unfolded Protein Response To Organonitrogen Compound Response To Endoplasmic Reticulum Stress Cellular Response To Stimulus Response To Toxic Substance Response To Hormone Small Molecule Metabolic Process Response To Drug Cellular Chemical Homeostasis Response To Stress Response To Abiotic Stimulus Erythrocyte Development Cellular Response To Nutrient Regulation Of Metabolic Process Positive Regulation Of Fat Cell Differentiation
Tagcloud ?		accelerated acetaldehyde belief blocker clonidine compartimentalization confirmation contrary da depend deprenyl elicit enhancers exceptions exists gbr mao metabolite mk mpp mptp nicotine offers produces rule sharp striatal striatum uneffective	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Difference) ?		accelerated acetaldehyde belief blocker clonidine compartimentalization confirmation contrary da depend deprenyl elicit enhancers exceptions exists gbr mao metabolite mk mpp mptp nicotine offers produces rule sharp striatal striatum uneffective	ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Intersection) ?