RETREG3 and ARHGAP27

		RETREG3	ARHGAP27
Description		reticulophagy regulator family member 3	Rho GTPase activating protein 27
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Endoplasmic Reticulum Tubular Network	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity	GTPase Activator Activity SH3 Domain Binding Actin Filament Binding
	Biological Process	Autophagy Endoplasmic Reticulum Organization Positive Regulation Of Neuron Projection Development Collagen Catabolic Process Reticulophagy Substrate Localization To Autophagosome Endoplasmic Reticulum Tubular Network Organization	Endocytosis Receptor-mediated Endocytosis Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization
Pathways			CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Hemoglobin levels ( 32327693) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Parkinson's disease ( 28892059) Refractive error ( 32231278) Systemic lupus erythematosus ( 29848360) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		107 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARLN ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6	3 interacting genes: CDC42 RAC1 SH3KBP1
Entrez ID		162427	201176
HPRD ID		14108	12477
Ensembl ID		ENSG00000141699	ENSG00000159314
Uniprot IDs		K7EQI9 Q86VR2	A0A8I5KVA8 E9PIR1 E9PNT2 E9PNX6 Q6ZUM4 Q8N2Y9
PDB IDs			3PP2
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Membrane Fusion Endomembrane System Organelle Fusion Organelle Membrane Fusion Membrane Organization Golgi Vesicle Transport Vesicle Fusion Protein Binding Organelle Localization By Membrane Tethering Vesicle Organization Lipid Biosynthetic Process Membrane Docking SNARE Binding Golgi Membrane Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Organization Vesicle Docking CDP-diacylglycerol Metabolic Process Transport Vesicle SNARE Complex Assembly Mitochondrial Outer Membrane Phosphatidylethanolamine Binding FFAT Motif Binding Endoplasmic Reticulum Membrane Organization Organelle Membrane Bounding Membrane Of Organelle Synaptic Vesicle Phospholipid Metabolic Process Azurophil Granule Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Phospholipid Biosynthetic Process Lipid Metabolic Process Establishment Of Protein Localization Late Endosome Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chloride Channel Inhibitor Activity Endoplasmic Reticulum Localization Serine Palmitoyltransferase Complex Positive Regulation Of B Cell Receptor Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Thioesterase Binding GTP-dependent Protein Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Phagocytosis, Engulfment Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Membrane Invagination Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Non-canonical Wnt Signaling Pathway Focal Adhesion Endocytosis Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Supramolecular Fiber Organization G Protein Activity Cytoplasmic Ribonucleoprotein Granule Glutamatergic Synapse Import Into Cell Regulation Of Stress Fiber Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell-substrate Adhesion Organelle Organization Regulation Of Postsynapse Organization GBD Domain Binding Storage Vacuole Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Regulation Of Cell Shape Cerebral Cortex GABAergic Interneuron Development Establishment Or Maintenance Of Cell Polarity Cell Migration Positive Regulation Of Supramolecular Fiber Organization Cell-cell Junction Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Cytoskeleton Organization Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Cytoskeleton Organization Cell-cell Junction
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