RETREG3 and RUNDC1

		RETREG3	RUNDC1
Description		reticulophagy regulator family member 3	RUN domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding Endoplasmic Reticulum-autophagosome Adaptor Activity
	Biological Process	Autophagy Endoplasmic Reticulum Organization Positive Regulation Of Neuron Projection Development Collagen Catabolic Process Reticulophagy Substrate Localization To Autophagosome Endoplasmic Reticulum Tubular Network Organization	In Utero Embryonic Development
Pathways
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		107 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARLN ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6	1 interacting genes: TNKS
Entrez ID		162427	146923
HPRD ID		14108	15283
Ensembl ID		ENSG00000141699	ENSG00000198863
Uniprot IDs		K7EQI9 Q86VR2	Q96C34
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Membrane Fusion Endomembrane System Organelle Fusion Organelle Membrane Fusion Membrane Organization Golgi Vesicle Transport Vesicle Fusion Protein Binding Organelle Localization By Membrane Tethering Vesicle Organization Lipid Biosynthetic Process Membrane Docking SNARE Binding Golgi Membrane Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Organization Vesicle Docking CDP-diacylglycerol Metabolic Process Transport Vesicle SNARE Complex Assembly Mitochondrial Outer Membrane Phosphatidylethanolamine Binding FFAT Motif Binding Endoplasmic Reticulum Membrane Organization Organelle Membrane Bounding Membrane Of Organelle Synaptic Vesicle Phospholipid Metabolic Process Azurophil Granule Membrane COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Phospholipid Biosynthetic Process Lipid Metabolic Process Establishment Of Protein Localization Late Endosome Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chloride Channel Inhibitor Activity Endoplasmic Reticulum Localization Serine Palmitoyltransferase Complex Positive Regulation Of B Cell Receptor Signaling Pathway	Negative Regulation Of Sister Chromatid Cohesion Positive Regulation Of Telomere Capping Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Endoplasmic Reticulum-autophagosome Adaptor Activity Telomerase Inhibitor Activity Substrate Localization To Autophagosome Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Peptidyl-threonine Phosphorylation Regulation Of Sister Chromatid Cohesion NAD+-protein Mono-ADP-ribosyltransferase Activity Protein Poly-ADP-ribosylation Endoplasmic Reticulum Tubular Network Reticulophagy Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Mitotic Spindle Pole Collagen Catabolic Process Regulation Of Telomere Maintenance Via Telomerase Peptidyl-serine Phosphorylation Positive Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Endoplasmic Reticulum Organization Collagen Metabolic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Nuclear Pore Regulation Of DNA Biosynthetic Process Mitotic Spindle Organization Spindle Assembly Nucleotidyltransferase Activity Protein Localization To Chromosome Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance
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