CYP51A1 and ZNF420

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CYP51A1	ZNF420
Gene Name		cytochrome P450, family 51, subfamily A, polypeptide 1	zinc finger protein 420
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Nucleus Extracellular Vesicular Exosome
	Molecular Function	Iron Ion Binding Sterol 14-demethylase Activity Heme Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Sterol Metabolic Process Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Small Molecule Metabolic Process Oxidation-reduction Process Demethylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Cholesterol biosynthesis Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Activation of gene expression by SREBF (SREBP) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Generic Transcription Pathway
Drugs		Tioconazole Itraconazole 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ZNF420	8 interactors: CDC42 CDK2AP1 CYP4V2 CYP51A1 HAX1 SLC1A7 TNFRSF1B TRIM28
Entrez ID		1595	147923
HPRD ID		03381	08122
Ensembl ID		ENSG00000001630	ENSG00000197050
Uniprot IDs		Q16850	Q8TAQ5
PDB IDs		3JUS 3JUV 3LD6
Enriched GO Terms of Interacting Partners?			Regulation Of Intracellular Protein Transport Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Transport Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Positive Regulation Of Protein Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of DNA Demethylation Positive Regulation Of Hair Follicle Cell Proliferation Fatty Acid Omega-oxidation Regulation Of Protein Transport Actin Filament Branching Submandibular Salivary Gland Formation Positive Regulation Of DNA Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Targeting To Mitochondrion Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Protein Phosphorylation Convergent Extension Involved In Axis Elongation Regulation Of Protein Localization Establishment Of Golgi Localization Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Transport Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Positive Regulation Of Granulocyte Differentiation Regulation Of Protein Heterodimerization Activity Regulation Of Mitochondrion Degradation Keratinocyte Development Regulation Of Synapse Structural Plasticity Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Positive Regulation Of Pseudopodium Assembly Nuclear Migration RNA Destabilization Cardiac Conduction System Development Convergent Extension Positive Regulation Of Membrane Protein Ectodomain Proteolysis Golgi Localization Negative Regulation Of Viral Release From Host Cell
Tagcloud ?		1h a431 bioinformatics bpa c4 cetuximab dimerization dramatic effectors egfr endocytic erbb3 eukaryotes extensively hypothesize identifies inactivation internalized ketoconazole nadp nsdhl rescued sc4mol sensitized sterol trafficking unexpected validate vesicular
Tagcloud (Difference) ?		1h a431 bioinformatics bpa c4 cetuximab dimerization dramatic effectors egfr endocytic erbb3 eukaryotes extensively hypothesize identifies inactivation internalized ketoconazole nadp nsdhl rescued sc4mol sensitized sterol trafficking unexpected validate vesicular
Tagcloud (Intersection) ?