CYP11B1

Description		cytochrome P450 family 11 subfamily B member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Monooxygenase Activity Steroid 11-beta-monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Corticosterone 18-monooxygenase Activity
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Immune Response Cholesterol Metabolic Process Regulation Of Blood Pressure Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Glucose Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B1 causes AH4
Drugs		Mitotane Metyrapone Levoketoconazole Osilodrostat
Diseases		Glucocorticoid-remediable aldosteronism (GRA) 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Congenital adrenal hyperplasia (CAH)
GWAS		Hypertension ( 30487518) Mean arterial pressure ( 30487518) Pulse pressure ( 30487518) Systolic blood pressure ( 29403010)
Interacting Genes		1 interacting genes: CYP11B2
Entrez ID		1584
HPRD ID		01943
Ensembl ID		ENSG00000160882
Uniprot IDs		P15538 Q8TDD0
PDB IDs		6M7X 7E7F
Enriched GO Terms of Interacting Partners?		Aldosterone Metabolic Process Mineralocorticoid Biosynthetic Process Steroid 11-beta-monooxygenase Activity Cortisol Biosynthetic Process Aldosterone Biosynthetic Process Regulation Of Blood Volume By Renal Aldosterone Glucocorticoid Biosynthetic Process Cortisol Metabolic Process Corticosterone 18-monooxygenase Activity Steroid Hydroxylase Activity C21-steroid Hormone Biosynthetic Process Positive Regulation Of Systemic Arterial Blood Pressure Cellular Response To Potassium Ion Glucocorticoid Metabolic Process Renal Water Homeostasis Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Response To Potassium Ion Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Multicellular Organismal-level Water Homeostasis C21-steroid Hormone Metabolic Process Steroid Hormone Biosynthetic Process Positive Regulation Of Blood Pressure Ketone Biosynthetic Process Hormone Biosynthetic Process Sodium Ion Homeostasis Potassium Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Aldehyde Metabolic Process Multicellular Organismal-level Chemical Homeostasis Ketone Metabolic Process Steroid Biosynthetic Process Cholesterol Metabolic Process Heme Binding Iron Ion Binding Renal System Process Sterol Metabolic Process Olefinic Compound Metabolic Process Regulation Of Blood Pressure Cellular Response To Metal Ion Cellular Response To Peptide Hormone Stimulus Hormone Metabolic Process Steroid Metabolic Process Alcohol Metabolic Process Regulation Of Body Fluid Levels Response To Peptide Hormone Response To Metal Ion Cellular Response To Hormone Stimulus Inorganic Ion Homeostasis
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