CYP1A1 and CEMIP

		CYP1A1	CEMIP
Description		cytochrome P450 family 1 subfamily A member 1	cell migration inducing hyaluronidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Fibrillar Center Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Membrane Nuclear Membrane Clathrin-coated Endocytic Vesicle
	Molecular Function	Catalytic Activity Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonate Monooxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Flavonoid 3'-monooxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Demethylase Activity Metal Ion Binding Hsp90 Protein Binding Vitamin D 24-hydroxylase Activity Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Long-chain Fatty Acid Omega-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity	Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Clathrin Heavy Chain Binding ER Retention Sequence Binding
	Biological Process	Response To Hypoxia Long-chain Fatty Acid Metabolic Process Liver Development Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Amine Metabolic Process Toxin Metabolic Process Response To Xenobiotic Stimulus Response To Nematode Response To Herbicide Response To Toxic Substance Ethylene Metabolic Process Coumarin Metabolic Process Flavonoid Metabolic Process Response To Iron(III) Ion Insecticide Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Dibenzo-p-dioxin Catabolic Process Epoxygenase P450 Pathway Response To Food Response To Lipopolysaccharide Response To Vitamin A Response To Genistein Response To Immobilization Stress Xenobiotic Catabolic Process Vitamin D Metabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process 9-cis-retinoic Acid Biosynthetic Process Camera-type Eye Development Nitric Oxide Metabolic Process Response To Arsenic-containing Substance Digestive Tract Development Tissue Remodeling Hydrogen Peroxide Biosynthetic Process Response To Hyperoxia Maternal Process Involved In Parturition Hepatocyte Differentiation Cellular Response To Copper Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Diphenyl Ether Response To Aroclor 1254 Response To 2,3,7,8-tetrachlorodibenzodioxine Response To 3-methylcholanthrene	Sensory Perception Of Sound Positive Regulation Of Peptidyl-threonine Phosphorylation Hyaluronan Metabolic Process Hyaluronan Biosynthetic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Kinase C Activity
Pathways		PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins	Hyaluronan degradation
Drugs		2-Methoxyestradiol Indirubin Nabiximols
Diseases
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Caffeine consumption ( 21490707) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Clozapine concentration in schizophrenia ( 32555152) Coffee consumption ( 21357676 31046077 21876539 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Diastolic blood pressure ( 19430483 21909115 26390057 27618452 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Microalbuminuria ( 31511532) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Platelet distribution width ( 27863252) Relative carbohydrate intake ( 32393786) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 28739976 21909115 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Urate levels ( 31578528) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189 30910378) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)	Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) HDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		2 interacting genes: CMTM5 CYB5A	1 interacting genes: PLXNA2
Entrez ID		1543	57214
HPRD ID		00148	10519
Ensembl ID		ENSG00000140465	ENSG00000103888
Uniprot IDs		A0N0X8 E7EMT5 P04798	Q8WUJ3
PDB IDs		4I8V 6DWM 6DWN 6O5Y 6UDL 6UDM
Enriched GO Terms of Interacting Partners?		Aflatoxin Metabolic Process Electron Transfer Activity Toxin Metabolic Process Secondary Metabolic Process Toxin Biosynthetic Process Heme Binding Cellular Respiration Demethylase Activity Caffeine Oxidase Activity Dibenzo-p-dioxin Metabolic Process Synaptic Vesicle To Endosome Fusion Presynaptic Endosome Membrane NADP+ Binding Toxin Catabolic Process Aflatoxin Catabolic Process Hyaluronan Biosynthetic Process Positive Regulation Of Protein Kinase C Activity	Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Tube Development Arachidonate Monooxygenase Activity Insecticide Metabolic Process Response To Diphenyl Ether Ethylene Metabolic Process Cerebellar Granule Cell Precursor Tangential Migration Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Response To Iron(III) Ion Demethylase Activity Dibenzo-p-dioxin Metabolic Process Coumarin Metabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Hindbrain Tangential Cell Migration Long-chain Fatty Acid Omega-hydroxylase Activity Lipid Hydroxylation Response To Phenylpropanoid Retinoic Acid Biosynthetic Process Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Response To 2,3,7,8-tetrachlorodibenzodioxine Estrogen 2-hydroxylase Activity Response To Nematode Limb Bud Formation Omega-hydroxylase P450 Pathway Flavonoid Metabolic Process Hydrogen Peroxide Biosynthetic Process Cell Migration In Hindbrain Response To Vitamin A Vitamin D Metabolic Process Semaphorin Receptor Activity Epoxygenase P450 Pathway Hepatocyte Differentiation Semaphorin Receptor Complex Reactive Oxygen Species Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Response To Hyperoxia Pharyngeal System Development Response To Immobilization Stress Cellular Response To Copper Ion
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