IRX2 and PLAGL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IRX2	PLAGL2
Description		iroquois homeobox 2	PLAG1 like zinc finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Cell Development Specification Of Loop Of Henle Identity Proximal/distal Pattern Formation Involved In Metanephric Nephron Development	Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Post-embryonic Development Chylomicron Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Nephron development
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Body mass index (adult) ( 28430825) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Toenail selenium levels ( 25343990)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		3 interacting genes: PFDN5 PLAGL2 TLE5	45 interacting genes: ANKRD11 ARID5A BCAS2 CATSPER1 CCDC120 CTNNA3 DAPP1 DHX57 DVL3 FAM161B FAM83A FAM90A1 GADD45G GEM GLYCTK GPATCH2L GYS1 INO80B IRX2 KANK2 MAD2L2 MAPK1 MORN4 NOS1AP OIP5 OLIG3 PAX9 PHC2 PIN1 PLAC8 PRR35 RCHY1 RHOBTB3 RIPPLY1 SAMD11 SEPHS1 SMARCD1 TEKT3 TEKT4 TRAF4 TRIM41 VEZF1 YPEL5 ZNF564 ZNF581
Entrez ID		153572	5326
HPRD ID		09368	05333
Ensembl ID		ENSG00000170561	ENSG00000126003
Uniprot IDs		Q9BZI1	Q9UPG8
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Wnt Signaling Pathway RNA Polymerase II Core Complex Assembly Transcription Corepressor Activity Chylomicron Assembly Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Anoikis Prefoldin Complex Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Amyloid Fibril Formation Plasma Lipoprotein Particle Assembly Regulation Of Anoikis Protein-lipid Complex Assembly Regulation Of Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Regulation Of Nucleobase-containing Compound Metabolic Process
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