CX3CL1

Description		C-X3-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Cell Projection Neuron Projection Neuronal Cell Body Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Chemokine Activity CX3C Chemokine Receptor Binding Chemoattractant Activity CXCR1 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Microglial Cell Activation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Leukocyte Migration Involved In Inflammatory Response Response To Ischemia Chemotaxis Defense Response Inflammatory Response Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Neuron Remodeling Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Neutrophil Chemotaxis Leukocyte Chemotaxis Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Integrin Activation Autocrine Signaling Wound Healing Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Leukocyte Adhesive Activation Positive Chemotaxis Positive Regulation Of Calcium-independent Cell-cell Adhesion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Cell Chemotaxis Microglial Cell Proliferation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neuron Cellular Homeostasis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Synapse Pruning Negative Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Negative Regulation Of Neuron Migration Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)
Interacting Genes		1 interacting genes: CX3CR1
Entrez ID		6376
HPRD ID		03529
Ensembl ID		ENSG00000006210
Uniprot IDs		A0N0N7 P78423
PDB IDs		1B2T 1F2L 3ONA 4XT1 4XT3 5WB2 7RKF 7RKM 7RKN 7XBX
Enriched GO Terms of Interacting Partners?		Multiple Spine Synapse Organization, Single Dendrite C-X3-C Chemokine Receptor Activity Negative Regulation Of Microglial Cell Mediated Cytotoxicity Macropinosome Membrane Central Nervous System Maturation CX3C Chemokine Receptor Binding Dendritic Tree Microglial Cell Activation Involved In Immune Response Regulation Of Hippocampal Neuron Apoptotic Process C-X3-C Chemokine Binding Negative Regulation Of Hippocampal Neuron Apoptotic Process Autocrine Signaling Regulation Of Microglial Cell Migration Host-mediated Modulation Of Intestinal Microbiota Composition Synapse Pruning Antifungal Innate Immune Response Synapse Maturation Chemokine Receptor Activity Positive Regulation Of Monocyte Chemotaxis Leukocyte Adhesion To Vascular Endothelial Cell Macrophage Activation Involved In Immune Response Leukocyte Tethering Or Rolling C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Glial Cell Migration Neuronal Cell Body Membrane Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Interleukin-1 Beta Production Microglial Cell Activation Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response G Protein-coupled Peptide Receptor Activity Negative Regulation Of Interleukin-1 Production Regulation Of Neuroblast Proliferation Regulation Of Macrophage Migration Cellular Defense Response Cytokine Receptor Activity Defense Response To Fungus Social Behavior Leukocyte Cell-cell Adhesion Positive Regulation Of Neural Precursor Cell Proliferation Response To Fungus Response To Ischemia Regulation Of Nitric Oxide Biosynthetic Process Macrophage Activation Regulation Of Nitric Oxide Metabolic Process Chemokine-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Migration Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis
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