TTC14 and CCDC39

		TTC14	CCDC39
Description		tetratricopeptide repeat domain 14	coiled-coil domain 39 molecular ruler complex subunit
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Cell Projection
	Molecular Function	Nucleic Acid Binding
	Biological Process		Heart Looping Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Regulation Of Cilium Beat Frequency Determination Of Left/right Symmetry Nervous System Development Brain Development Heart Development Microglia Differentiation Cerebral Cortex Development Central Nervous System Myelination Flagellated Sperm Motility Lung Development Determination Of Pancreatic Left/right Asymmetry Inner Dynein Arm Assembly Locomotion Neuron Maturation Motile Cilium Assembly Neuron Projection Morphogenesis Establishment Of Localization In Cell Synapse Maturation Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Protein Localization To Cilium Establishment Of Left/right Asymmetry Axonemal Dynein Complex Assembly Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry Cerebrospinal Fluid Circulation Neuroinflammatory Response
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Glucose homeostasis traits ( 25524916)	BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Schizophrenia ( 25056061)
Interacting Genes		11 interacting genes: CCDC85B CHERP ESS2 FRA10AC1 IK NKAP RBM39 SF3B2 SNIP1 SNW1 SRRM2
Entrez ID		151613	339829
HPRD ID		15579	13185
Ensembl ID		ENSG00000163728	ENSG00000284862
Uniprot IDs		Q96N46	Q9UFE4
PDB IDs			8J07
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Processing MRNA Metabolic Process Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome RNA Metabolic Process Nuclear Speck Nucleic Acid Metabolic Process RNA Binding Nucleobase-containing Compound Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Catalytic Step 2 Spliceosome Spliceosomal Complex Assembly Nucleus Nucleoplasm	Nucleic Acid Binding
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