FIGLA and LHX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FIGLA	LHX6
Description		folliculogenesis specific bHLH transcription factor	LIM homeobox 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Oocyte Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Tangential Migration Cerebral Cortex GABAergic Interneuron Migration Forebrain Neuron Development Cell Differentiation Neuron Differentiation Cell Maturation
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181)	Malaria ( 31844061)
Interacting Genes		7 interacting genes: LHX3 LHX6 LHX8 MYF5 MYOD1 MYOG TCF23	8 interacting genes: CPNE1 FAM90A1 FIGLA KLF3 NRF1 ROR2 ZNF138 ZNF76
Entrez ID		344018	26468
HPRD ID		12279	10498
Ensembl ID		ENSG00000183733	ENSG00000106852
Uniprot IDs		Q6QHK4	Q9UPM6
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Positive Regulation Of Skeletal Muscle Fiber Development Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development Muscle Organ Development Muscle Structure Development Regulation Of Muscle Cell Differentiation Protein Dimerization Activity Regulation Of Striated Muscle Tissue Development Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Cell Differentiation E-box Binding Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Development Positive Regulation Of Muscle Cell Differentiation Regulation Of Myoblast Differentiation Cellular Developmental Process Regulation Of Striated Muscle Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Striated Muscle Tissue Development DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Regulation Of Myoblast Fusion Forebrain Neuron Development Cell Fate Commitment Myotube Differentiation DNA-binding Transcription Activator Activity Sequence-specific Double-stranded DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Skeletal Muscle Fiber Development Animal Organ Development Myotube Cell Development Cellular Response To Estradiol Stimulus Transcription Regulator Complex Tissue Development Regulation Of Gene Expression	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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