OTOS and NGB

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		OTOS	NGB
Description		otospiralin	neuroglobin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding	GDP-dissociation Inhibitor Activity Oxygen Carrier Activity Protein Binding Oxidoreductase Activity Oxygen Binding Heme Binding Metal Ion Binding Nitrite Reductase Activity
	Biological Process	Sensory Perception Of Sound	Response To Hypoxia Oxygen Transport Cellular Response To Hypoxia
Pathways			Intracellular oxygen transport
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27694959) Tinnitus in cisplatin-treated testicular cancer ( 30952644)
Interacting Genes		7 interacting genes: ATG13 CCDC125 CYSRT1 GNMT NGB RAB2A VAC14	23 interacting genes: AKT1 ATP1B2 BTBD2 C1orf94 DDIT4L FLOT1 GATAD2B GNAI1 GNAI2 GNAI3 GNAO1 IHO1 L3MBTL3 MAPK14 MEI4 NIF3L1 OTOS PTEN REL TDO2 TEPSIN VAC14 ZNF655
Entrez ID		150677	58157
HPRD ID		09714	05602
Ensembl ID		ENSG00000178602	ENSG00000165553
Uniprot IDs		Q8NHW6	A0M8W9 Q9NPG2
PDB IDs			1OJ6 4MPM 7VQG 8GRZ 8WUB
Enriched GO Terms of Interacting Partners?			Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Meiotic DNA Double-strand Break Formation Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding Regulation Of Transport Myelin Maintenance Positive Regulation Of Myoblast Fusion Regulation Of Organ Growth Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Myoblast Fusion G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Peptidyl-serine Phosphorylation Osteoblast Differentiation Response To Prostaglandin E Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Ciliary Basal Body Regulation Of Cholesterol Biosynthetic Process Centriolar Satellite Homologous Chromosome Pairing At Meiosis Positive Regulation Of Sodium Ion Transport GTPase Activity Positive Regulation Of D-glucose Import Regulation Of Smooth Muscle Cell Proliferation Regulation Of TRNA Methylation Positive Regulation Of Steroid Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Neuronal-glial Interaction Involved In Hindbrain Glial-mediated Radial Cell Migration Negative Regulation Of Secretion By Cell Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Negative Regulation Of Synaptic Vesicle Clustering L-tryptophan Catabolic Process To Acetyl-CoA PAS Complex Coated Vesicle Membrane Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Insulin Secretion GTP Binding Positive Regulation Of Steroid Metabolic Process
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