HORMAD2 and NSD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HORMAD2	NSD2
Description		HORMA domain containing 2	nuclear receptor binding SET domain protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Centrosome Cytosol	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	Meiotic Sister Chromatid Cohesion Meiotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases			Multiple myeloma
GWAS		Albumin-globulin ratio ( 29403010) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Behcet's disease ( 33393726) Cataracts ( 34127677) Creatine kinase levels ( 29403010) Crohn's disease ( 28067908) Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) IgA nephropathy ( 26028593 32912934 25305756) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Medication use (thyroid preparations) ( 31015401) Moyamoya disease ( 29273593) Nephropathy ( 21399633) Neutrophil percentage of white cells ( 27863252 32888494) Non-albumin protein levels ( 29403010) Optic cup area ( 31798171) Optic disc area ( 25631615) Tonsillectomy ( 27941131) Type 1 diabetes ( 30572963) Type 2 diabetes ( 30054458) Vertical cup-disc ratio ( 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		2 interacting genes: NSD2 SYCP2	15 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H19 H3-4 H3C1 H3C14 HORMAD2 MDC1 PCNA PLEKHF2 TP53
Entrez ID		150280	7468
HPRD ID		13668	04259
Ensembl ID		ENSG00000176635	ENSG00000109685
Uniprot IDs		Q8N7B1	O96028
PDB IDs			5LSU 5VC8 6UE6 6XCG 7CRO 7E8D 7LMT 7MDN 7VLN 9EXW 9EXX 9EXY 9GBF
Enriched GO Terms of Interacting Partners?		Histone H3K36 Trimethyltransferase Activity Positive Regulation Of Isotype Switching To IgA Isotypes Atrial Septum Secundum Morphogenesis Atrial Septum Primum Morphogenesis Histone H3K36 Dimethyltransferase Activity Male Genitalia Morphogenesis Histone H4K20 Methyltransferase Activity Histone H3K36 Methyltransferase Activity Membranous Septum Morphogenesis Chromosome Genitalia Morphogenesis Lateral Element Histone H3 Methyltransferase Activity Atrial Septum Morphogenesis Synaptonemal Complex Condensed Chromosome, Centromeric Region Programmed Cell Death Involved In Cell Development Synaptonemal Complex Assembly Synaptonemal Complex Organization Ectopic Germ Cell Programmed Cell Death Female Meiotic Nuclear Division Positive Regulation Of Isotype Switching Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Histone Methyltransferase Activity Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Male Meiotic Nuclear Division Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of Immunoglobulin Production Anatomical Structure Morphogenesis Negative Regulation Of Reproductive Process Positive Regulation Of DNA Recombination Cardiac Septum Morphogenesis Bone Development Meiotic Nuclear Division Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Activation Nuclear Division	Chromatin Organization Nucleoplasm Enzyme Binding Chromatin Remodeling Chromatin Binding Regulation Of MiRNA Transcription Protein Heterodimerization Activity Regulation Of MiRNA Metabolic Process Molecular Function Activator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Developmental Growth Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Reproductive Process Prostate Gland Growth Nuclear Body Mitotic DNA Damage Checkpoint Signaling Protein-DNA Complex Assembly Estrogen Response Element Binding Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Chromosome Positive Regulation Of Reproductive Process Nucleus Macromolecule Metabolic Process Structural Constituent Of Chromatin Protein-containing Complex Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Core Promoter Sequence-specific DNA Binding Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Nucleosome Assembly DNA Binding Regulation Of Cellular Response To Stress Gene Expression Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Cellular Response To Oxygen-containing Compound Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II
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