AANAT and KRTAP8-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AANAT	KRTAP8-1
Description		aralkylamine N-acetyltransferase	keratin associated protein 8-1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Cytosol Intermediate Filament
	Molecular Function	Aralkylamine N-acetyltransferase Activity Arylamine N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups 14-3-3 Protein Binding	Protein Binding
	Biological Process	N-terminal Protein Amino Acid Acetylation Circadian Rhythm Response To Light Stimulus Photoperiodism Response To Zinc Ion Melatonin Biosynthetic Process Response To Insulin Response To Cytokine Response To Prostaglandin E Indolalkylamine Biosynthetic Process Response To Copper Ion Rhythmic Process Response To Corticosterone Response To CAMP Response To Calcium Ion Cellular Response To CAMP Response To Peptide
Pathways		Serotonin and melatonin biosynthesis	Keratinization
Drugs		CoA-S-trimethylene-acetyl-tryptamine CoA-s-acetyl tryptamine CoA-S-acetyl 5-bromotryptamine Cannabidiol Medical Cannabis Nabiximols
Diseases		Delayed sleep phase syndrome
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)	Gut microbiota (bacterial taxa) ( 27723756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		8 interacting genes: BHLHE40 EIF4E3 F2 GRB10 KRTAP8-1 MDFI PRKACA YWHAZ	78 interacting genes: AANAT AGXT AOC1 ARID5A ATG9A ATXN1L BANP BCAS2 BHLHE40 C11orf16 C1orf94 CAMK2A CCDC17 CCNK CDA CERCAM CIMIP1 CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRTB1 DTX2 FAAP20 FAM168A FAM83A FOXD2 FOXP3 GATA2 GCM2 GLIS2 HEY2 HOXC8 HYPK KRTAP12-4 KRTAP19-5 KRTAP26-1 MKRN3 MYOZ3 NKX2-5 NOXA1 P4HA3 PAX3 PITX1 PLSCR4 POGZ POU6F2 PROP1 PRR13 PRR35 PSMA3 RAMAC RBPMS RBPMS2 RNF38 RUSC1 SAXO4 SLC68A1 SMR3A SMUG1 SNRPC TBX18 TEKT3 TIAL1 TLE5 TLX3 TMSB4X TNIP1 TNPO2 TSPYL6 VENTX VEZF1 YTHDF1 ZBTB32 ZC3H10 ZIC1 ZNF34
Entrez ID		15	337879
HPRD ID		02974	11221
Ensembl ID		ENSG00000129673	ENSG00000183640
Uniprot IDs		F1T0I5 Q16613	Q8IUC2
PDB IDs		6T80
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Survivin Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process ERK1 And ERK2 Cascade Protein Sequestering Activity Protein Domain Specific Binding Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Macromolecule Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Negative Regulation Of TOR Signaling TOR Signaling Synaptic Target Recognition Regulation Of TORC1 Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Exit From Mitosis Cobalt Ion Binding Regulation Of Metabolic Process Regulation Of Sequestering Of Calcium Ion Blood Microparticle Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Thrombospondin Receptor Activity Regulation Of Generation Of Precursor Metabolites And Energy Vascular Associated Smooth Muscle Cell Migration Tube Formation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Interphase Microtubule Organizing Center Regulation Of Gene Expression Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Golgi Reassembly MRF Binding Regulation Of TOR Signaling Regulation Of Cell Communication Negative Regulation Of DNA-templated Transcription Chromosome Passenger Complex Regulation Of Signaling Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Localization To Nucleus	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Chromatin DNA Binding Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Cytoplasmic Stress Granule Protein Homodimerization Activity Identical Protein Binding Regulation Of Gene Expression Nucleoplasm Regulation Of Primary Metabolic Process Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Muscle Cell Differentiation Pituitary Gland Development Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Cardiac Muscle Cell Fate Commitment Central Nervous System Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Cardiac Cell Development
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