PROSER3 and CCDC146

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PROSER3	CCDC146
Description		proline and serine rich 3	coiled-coil domain containing 146
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton	Cytoplasm Centrosome Centriole Cytoskeleton Cilium Axoneme Midbody Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Sperm Head-tail Coupling Apparatus
	Molecular Function	Protein Binding	Protein Binding Protein-containing Complex Binding
	Biological Process		Cell Morphogenesis Nucleus Organization Spermatogenesis Spermatid Development Sperm Axoneme Assembly Single Fertilization Cell Population Proliferation Gene Expression Cell Differentiation Flagellated Sperm Motility Cilium Organization Sperm Flagellum Assembly Manchette Assembly
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	Amyloid beta positivity ( 34154648) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Macrovascular complications in type 2 diabetes ( 33430853) Ophthalmic complications in type 2 diabetes ( 33430853) Response to amphetamines ( 22952603)
Interacting Genes		8 interacting genes: CCDC146 CCDC57 CCHCR1 CDC23 IQCC NME7 SGF29 ZNF396	71 interacting genes: AKAP9 BLOC1S2 CBY2 CCDC136 CCDC197 CCNDBP1 CDR2 CDR2L CENPH CEP170P1 CEP44 CFTR DRC4 DTNBP1 FSD2 GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 HSF2BP INSYN1 KIFC3 KRT16 KRT18 KRT19 KRT24 KRT26 KRT27 KRT31 KRT34 KRT38 KRT40 KRT86 LHX3 MAGEA11 MAGEA6 MCC MED4 MIPOL1 MRFAP1 MTUS2 N4BP3 NAP1L2 NECAB2 NINL NUP62 PDE4DIP PLEKHF2 PNMA1 PPP2R3C PROSER3 PSMC6 RINT1 RNF40 RPGRIP1 SH3BP1 SYCE1L TEPSIN TFIP11 THOC7 TNR TPM3 TRAF1 TRIM23 TRIM54 TRIML2 TSC22D4 TXLNA USHBP1 VPS28 VPS52
Entrez ID		148137	57639
HPRD ID		14079	11150
Ensembl ID		ENSG00000167595	ENSG00000135205
Uniprot IDs		A0A2R8Y8D9 A0A8Q3WKY3 A0A8Q3WKY6 A0A8Q3WKY7 Q2NL68	Q8IYE0 Q96MS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Centriole Cilium Organization Cilium Assembly Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Mitotic Cell Cycle Sperm Flagellum Flagellated Sperm Motility Cilium Movement Involved In Cell Motility Sperm Motility Cilium-dependent Cell Motility Methylation-dependent Protein Binding	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Cytoskeleton Structural Molecule Activity Organelle Organization Supramolecular Fiber Organization Epithelial Cell Differentiation Microtubule-based Process Protein Binding Morphogenesis Of An Epithelium Centrosome Cycle Tissue Morphogenesis Microtubule Nucleation Centrosome Microtubule Organizing Center Organization Microtubule Cytoskeleton Organization Microtubule Binding Vesicle Transport Along Microtubule
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