WIPF2 and PTP4A2

Number of citations of the paper that reports this interaction (PubMedID 36300783)
81

Data Source:
BioGRID (pull down)

		WIPF2	PTP4A2
Description		WAS/WASL interacting protein family member 2	protein tyrosine phosphatase 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane
	Molecular Function	Actin Binding Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity
	Biological Process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	RAB geranylgeranylation
Drugs
Diseases
GWAS		Asthma ( 31619474) Blond vs. brown/black hair color ( 30531825) Household income (MTAG) ( 31844048) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Appendicular lean mass ( 33097823) Body mass index ( 26426971)
Interacting Genes		13 interacting genes: APBB1 DNMBP GRB2 ITSN2 NCK2 PFN1 PTP4A2 SORBS3 TCERG1 TVP23A WAS WASL WWOX	13 interacting genes: AKAP8L ATF7 CARS1 CNNM1 CNNM3 DHX15 DUSP22 EWSR1 HSP90AA1 HSP90AB1 MPO RABGGTB WIPF2
Entrez ID		147179	8073
HPRD ID		18304	03348
Ensembl ID		ENSG00000171475	ENSG00000184007
Uniprot IDs		Q8TF74	Q12974
PDB IDs			5K22 5K23 5K25 6WUR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Supramolecular Fiber Organization Phosphotyrosine Residue Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Stress Fiber Assembly Proline-rich Region Binding Positive Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Positive Regulation Of Transcription By RNA Polymerase II GTPase Regulator Activity Actin Filament-based Process Negative Regulation Of Stress Fiber Assembly Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Cell-cell Junction Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Organelle Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Projection Assembly Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of T Cell Antigen Processing And Presentation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Actin Polymerization Or Depolymerization Actin Filament Organization Actin Filament-based Movement Cytosol Positive Regulation Of Actin Filament Bundle Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Transcription Coactivator Activity Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Cell Projection Organization Regulation Of Organelle Organization T Cell Activation	Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Magnesium Ion Homeostasis Axonal Growth Cone Chaperone-mediated Protein Complex Assembly RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Telomere Maintenance Via Telomerase Histone Deacetylase Binding Disordered Domain Specific Binding DNA Polymerase Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Tyrosine Kinase Binding Tau Protein Binding CTP Binding DATP Binding Cellular Response To Heat Hypochlorous Acid Biosynthetic Process Protein Folding Chaperone Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation Double-stranded RNA Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Response To Gold Nanoparticle U2-type Post-mRNA Release Spliceosomal Complex Response To Alkaloid DNA Biosynthetic Process Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding Chromosome Organization Response To Heat Neuronal Cell Body Response To Transition Metal Nanoparticle Leading Edge Of Lamellipodium ATP Hydrolysis Activity Telomere Maintenance Melanosome Phagocytic Vesicle Lumen Rab-protein Geranylgeranyltransferase Complex
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