KCTD11 and KCTD15

Number of citations of the paper that reports this interaction (PubMedID 37597490)
46

Data Source:
BioGRID (pull down)

		KCTD11	KCTD15
Description		potassium channel tetramerization domain containing 11	potassium channel tetramerization domain containing 15
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus
	Molecular Function	Transferase Activity Identical Protein Binding	Transcription Corepressor Activity Protein Binding Identical Protein Binding
	Biological Process	Smoothened Signaling Pathway Nervous System Development Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Neuroblast Differentiation Protein Ubiquitination Neuron Differentiation Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Differentiation Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization	Negative Regulation Of DNA-templated Transcription Protein Homooligomerization
Pathways			Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Drugs
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 19079260 19079261 20935630 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Disease progression in age-related macular degeneration ( 29346644) Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight ( 19079260)
Interacting Genes		3 interacting genes: CUL3 HDAC1 KCTD15	16 interacting genes: ATXN1 CYSRT1 ENSA KCTD1 KCTD11 KCTD21 NBPF19 NOTCH2NLA NOXA1 NTAQ1 REN TFAP2A TRIM27 TRIM55 TRIM63 WIPI1
Entrez ID		147040	79047
HPRD ID		13763	13765
Ensembl ID		ENSG00000213859	ENSG00000153885
Uniprot IDs		A0A158RFT7 Q693B1	Q96SI1
PDB IDs			8PNM 8PNR
Enriched GO Terms of Interacting Partners?		Hair Follicle Placode Formation Transcription Corepressor Activity Krueppel-associated Box Domain Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Sperm Flagellum Regulation Protein Catabolic Process At Postsynapse Trophectodermal Cellular Morphogenesis POZ Domain Binding Motile Cilium Liver Morphogenesis Polar Microtubule Inner Dynein Arm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-containing Complex Assembly Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Myotube Differentiation Host-mediated Suppression Of Viral Transcription Histone Deacetylase Activity Negative Regulation Of RNA Metabolic Process Embryonic Morphogenesis Eyelid Development In Camera-type Eye Sin3-type Complex RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Animal Organ Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Host-mediated Suppression Of Viral Proces Protein Deacetylation NuRD Complex Protein Lysine Deacetylase Activity Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Core Promoter Sequence-specific DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Regulation Of Cell Fate Specification Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Rho Protein Signal Transduction Renal Sodium Ion Transport Positive Regulation Of Mitotic Sister Chromatid Separation Protein-containing Complex Organization Embryonic Cleavage Notch Binding Ubiquitin Ligase Complex Scaffold Activity Cullin-RING Ubiquitin Ligase Complex Contractile Actin Filament Bundle Assembly	Identical Protein Binding
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