PHETA1 and C11orf68

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHETA1	C11orf68
Description		PH domain containing endocytic trafficking adaptor 1	chromosome 11 open reading frame 68
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GO Annotations	Cellular Component	Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle Recycling Endosome
	Molecular Function	Protein Binding Protein Homodimerization Activity	RNA Binding Protein Binding
	Biological Process	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Asthma ( 31959851)
Interacting Genes		14 interacting genes: ABI2 C11orf68 CYSRT1 FCHO1 GRB2 HOXA1 KRTAP1-3 KRTAP13-2 KRTAP6-3 NCK2 OIP5 PLEKHJ1 SNCA SORBS3	14 interacting genes: CSDE1 EIF4H KCNE3 KLF15 MEOX2 MTCL1 NONO PHETA1 REL SDCBP SH3GL3 TRAPPC2L ZNF341 ZNF512B
Entrez ID		144717	83638
HPRD ID		08127	12553
Ensembl ID		ENSG00000198324	ENSG00000175573
Uniprot IDs		Q8N4B1	Q9H3H3
PDB IDs		3QIS	1ZTP 2Q4K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Organization Positive Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Cytoskeletal Anchor Activity Regulation Of Actin Filament-based Process Intermediate Filament Receptor-mediated Endocytosis Vesicle Membrane Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Actin Filament Polymerization Semicircular Canal Formation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Cellular Component Organization Receptor Internalization Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Grb2-EGFR Complex Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Abducens Nerve Formation Optokinetic Behavior Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Zonula Adherens Assembly Identical Protein Binding ERBB Signaling Pathway Regulation Of Organelle Organization Signaling Adaptor Activity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Protein Polymerization Cytosol Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Pericentric Heterochromatin Organization CENP-A Recruiting Complex
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