PARP4 and MVP

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		PARP4	MVP
Description		poly(ADP-ribose) polymerase family member 4	major vault protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Spindle Microtubule Membrane Extracellular Exosome Ribonucleoprotein Complex	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	DNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	DNA Repair Inflammatory Response DNA Damage Response Response To Xenobiotic Stimulus Protein Modification Process	Cell Population Proliferation Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein	Neutrophil degranulation
Drugs
Diseases
GWAS		Idiopathic intracranial hypertension ( 29608535) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)	Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: CCT6A MVP RNF10 SMAD3	69 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DTX2 EPHX2 ESR1 FMR1 FNDC3B FXR1 FXR2 GIT2 GOLGA2 HP HSPA13 IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF10 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2
Entrez ID		143	9961
HPRD ID		09598	05475
Ensembl ID		ENSG00000102699	ENSG00000013364
Uniprot IDs		Q9UKK3	Q14764 X5D2M8 X5D7K9 X5DNU0
PDB IDs		8SWY 8SWZ 8SX1 8SX2 9BW6 9BW7	1Y7X 9BW5 9BW6 9BW7 9MXH 9MXV
Enriched GO Terms of Interacting Partners?		Regulation Of Telomerase RNA Localization To Cajal Body Microtubule WD40-repeat Domain Binding Regulation Of Establishment Of Protein Localization To Chromosome Protein Stabilization Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Telomerase RNA Localization To Cajal Body Regulation Of Protein Localization To Nucleus Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Establishment Of Protein Localization To Telomere Sterol Response Element Binding Transdifferentiation Positive Regulation Of Transforming Growth Factor Beta3 Production SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Negative Regulation Of Osteoblast Proliferation Regulation Of Lung Blood Pressure Co-SMAD Binding Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Negative Regulation Of Lung Blood Pressure Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nodal Signaling Pathway Transcription Cis-regulatory Region Binding Heteromeric SMAD Protein Complex Positive Regulation Of Extracellular Matrix Assembly Trophoblast Cell Migration Nuclear Mineralocorticoid Receptor Binding Primary MiRNA Processing Embryonic Foregut Morphogenesis Immune System Development Regulation Of Transforming Growth Factor Beta2 Production Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Regulation Of Protein Stability DNA-binding Transcription Repressor Activity Transforming Growth Factor Beta Receptor Binding Osteoblast Development Nuclear Glucocorticoid Receptor Binding I-SMAD Binding Negative Regulation Of Cytosolic Calcium Ion Concentration	Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Biosynthetic Process Cytoplasm Regulation Of Neurogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity PML Body Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nervous System Development Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Translation Regulator Activity Regulation Of Neuronal Synaptic Plasticity TFIIB-class Transcription Factor Binding Viral Penetration Into Host Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase Benzodiazepine Receptor Binding Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Strand Annealing Activity Regulation Of MiRNA-mediated Gene Silencing Somite Specification Dentate Gyrus Development Single-stranded Telomeric DNA Binding MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Viral Process Protein Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chromosome Organization Positive Regulation Of Neurogenesis Intracellular Membraneless Organelle Presynapse Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process
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