PARP4

Description		poly(ADP-ribose) polymerase family member 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Spindle Microtubule Membrane Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	DNA Binding NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	DNA Repair Inflammatory Response DNA Damage Response Response To Xenobiotic Stimulus Protein Modification Process
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS		Idiopathic intracranial hypertension ( 29608535) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Novel Interacting Genes		1 novel interacting genes: TUBA3C
Interacting Genes		4 interacting genes: CCT6A MVP RNF10 SMAD3
Entrez ID		143
HPRD ID		09598
Ensembl ID		ENSG00000102699
Uniprot IDs		Q9UKK3
PDB IDs		8SWY 8SWZ 8SX1 8SX2 9BW6 9BW7
Enriched GO Terms of Interacting Partners?		Regulation Of Telomerase RNA Localization To Cajal Body Microtubule WD40-repeat Domain Binding Regulation Of Establishment Of Protein Localization To Chromosome Protein Stabilization Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Telomerase RNA Localization To Cajal Body Regulation Of Protein Localization To Nucleus Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Establishment Of Protein Localization To Telomere Sterol Response Element Binding Transdifferentiation Positive Regulation Of Transforming Growth Factor Beta3 Production SMAD Protein Complex Pericardium Development DEAD/H-box RNA Helicase Binding Negative Regulation Of Osteoblast Proliferation Regulation Of Lung Blood Pressure Co-SMAD Binding Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Negative Regulation Of Lung Blood Pressure Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nodal Signaling Pathway Transcription Cis-regulatory Region Binding Heteromeric SMAD Protein Complex Positive Regulation Of Extracellular Matrix Assembly Trophoblast Cell Migration Nuclear Mineralocorticoid Receptor Binding Primary MiRNA Processing Embryonic Foregut Morphogenesis Immune System Development Regulation Of Transforming Growth Factor Beta2 Production Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Regulation Of Protein Stability DNA-binding Transcription Repressor Activity Transforming Growth Factor Beta Receptor Binding Osteoblast Development Nuclear Glucocorticoid Receptor Binding I-SMAD Binding Negative Regulation Of Cytosolic Calcium Ion Concentration
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